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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 78705
Country/Territory United States
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report
Manuscript Source Unsolicited Manuscript
All Author List Venkata Vinod Kumar Matli, Gazi B Zibari, Gregory Wellman, Poornima Ramadas, Sudha Pandit and James Morris
Funding Agency and Grant Number
Corresponding Author Venkata Vinod Kumar Matli, MD, Attending Doctor, Department of Internal Medicine, Christus Highland Medical Center, 1455 E Bert Kouns Industrial Loop Christus Highland Medical Center , Shreveport, LA 71106, United States. vmatli@soundphysicians.com
Key Words Tubulovillous adenoma of the ampulla of Vater; Ampullary adenocarcinoma; Gastrointestinal stromal tumor; Ampullary polyp; Small bowel mesenchymal tumor; Case report
Core Tip This case is distinctive because the patient was diagnosed with two synchronous and extremely rare high-grade primary malignancies, i.e., an ampullary adenocarcinoma arising from a high-grade dysplastic tubulovillous adenoma of the ampulla of Vater (TVAoA) with a high-grade ileal gastrointestinal stromal tumor (GIST). Based on a literature review, this is the first report of an ampullary adenocarcinoma coexisting with an ileal GIST. AoA may occur sporadically or in a familial inheritance pattern, as in the setting of familial adenomatous polyposis syndrome (FAPS). We emphasize the need for screening and surveillance colonoscopy when one encounters an AoA in upper endoscopy to check for FAPS. TVAoA is a premalignant lesion, particularly in the setting of FAPS, and carries a high risk for metamorphism to an ampullary adenocarcinoma.
Citation Matli VVK, Zibari GB, Wellman G, Ramadas P, Pandit S, Morris J. Rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report. World J Gastrointest Oncol 2022; 14(11): 2253-2265
Received
2022-07-11 02:50
Peer-Review Started
2022-07-11 02:52
To Make the First Decision
Return for Revision
2022-08-22 01:33
Revised
2022-09-15 16:20
Second Decision
2022-09-26 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-10-02 22:37
Articles in Press
2022-10-02 22:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-11-04 07:02
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright All the authors report no relevant conflicts of interest for this article.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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