Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	78818
Country	China

Category	Oncology
Manuscript Type	Prospective Study
Article Title	Real-time in vivo distal margin selection using confocal laser endomicroscopy in transanal total mesorectal excision for rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Tan, Hong-Li Ji, Yao-Wen Hu, Zhi-Ming Li, Bao-Xiong Zhuang, Hai-Jun Deng, Ya-Nan Wang, Ji-Xiang Zheng, Wei Jiang and Jun Yan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82273360 Science and Technology Planning Project of Guangzhou City 202206010085 Clinical Research Project of Southern Medical University LC2016PY010 Clinical Research Project of Nanfang Hospital 2018CR034
Corresponding Author	Jun Yan, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Nanfang Hospital, No. 1838 North Guangzhou Road, Guangzhou 510515, Guangdong Province, China. yanjunfudan@163.com
Key Words	Transanal total mesorectal excision; Probe-based confocal laser endomicroscopy; Optical biopsy; Distal resection margin; Low rectal cancer
Core Tip	Transanal total mesorectal excision (TaTME) allows patients even with ultra-low rectal cancer to be treated with sphincter-saving surgery. However, low rectal cancer resection with sphincter preservation may lead to a positive distal resection margin (DRM), with a high risk for local recurrence. Confocal laser endomicroscopy (CLE) enables the real-time, in vivo optical biopsy of living tissue. Real-time in vivo probe-based CLE examination can provide optical biopsy and is feasible and safe for selecting the DRM during TaTME for low rectal cancer.
Citation	Tan J, Ji HL, Hu YW, Li ZM, Zhuang BX, Deng HJ, Wang YN, Zheng JX, Jiang W, Yan J. Real-time in vivo distal margin selection using confocal laser endomicroscopy in transanal total mesorectal excision for rectal cancer. World J Gastrointest Surg 2022; 14(12): 1375-1386

Received	2022-07-16 08:28
Peer-Review Started	2022-07-16 08:31
To Make the First Decision
Return for Revision	2022-10-30 22:55
Revised	2022-11-13 14:40
Second Decision	2022-12-05 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-12-06 18:05
Articles in Press	2022-12-06 18:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-08 00:57

ISSN	1948-9366 (online)
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