Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	78843
Country	United States

Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Gastrointestinal histoplasmosis complicating pediatric Crohn disease: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	C Quinn Miller, Omer A M Saeed and Katrina Collins
Funding Agency and Grant Number
Corresponding Author	Katrina Collins, MD, Assistant Professor, Department of Pathology, Indiana University School of Medicine, 350 W 11th Street, Indianapolis, IN 46202, United States. katcoll@iu.edu
Key Words	Crohn disease; Disseminated histoplasmosis; Endoscopy; Colon; Inflammatory bowel disease; Immunosuppression; Case report
Core Tip	Impaired cell-mediated immunity is known to increase the risk for disseminated histoplasmosis and has been described in the setting of Crohn disease (CD) treated with immunosuppressant agents. Endoscopically, the appearance of histoplasmosis varies and includes features of inflammatory mucosal changes. Increasing awareness of this condition is critical to avoid misdiagnosis and inappropriate treatment, particularly in the setting of underlying CD. While no specific recommendations are available, immunosuppressive therapy may be safely initiated in some cases when there appears to be effective response to antifungal therapy and the patient can be monitored closely.
Citation	Miller CQ, Saeed OAM, Collins K. Gastrointestinal histoplasmosis complicating pediatric Crohn disease: A case report and review of literature. World J Gastrointest Endosc 2022; 14(10): 648-656

Received	2022-07-17 18:22
Peer-Review Started	2022-07-17 18:25
To Make the First Decision
Return for Revision	2022-09-05 09:35
Revised	2022-09-05 20:45
Second Decision	2022-09-19 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-09-21 18:21
Articles in Press	2022-09-21 18:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-09-27 00:22

ISSN	1948-5190 (online)
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