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Publication Name World Journal of Gastroenterology
Manuscript ID 79311
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice
Manuscript Source Unsolicited Manuscript
All Author List Zhao-Xiu Liu, Wei-Jie Chen, Yang Wang, Bing-Qian Chen, Yi-Cun Liu, Tiao-Chun Cheng, Lei-Lei Luo, Lin Chen, Lin-Ling Ju, Yuan Liu, Ming Li, Nan Feng, Jian-Guo Shao and Zhao-Lian Bian
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Bureau MS22018007
Six peak talents in Jiangsu Province YY-177
Project of Jiangsu Province Youth Medical Talent Development QNRC2016400, QNRC2016697
Project of Nantong Youth Medical Talent Development No.05
Youth Fund of National Natural Science Foundation of China 82000497
Youth Fund of Natural Science Foundation of Jiangsu Province BK20200965
Scientific Research Fund of Nantong Health Commission MB2020037
Corresponding Author Zhao-Lian Bian, MD, PhD, Associate Chief Physician, Associate Professor, Doctor, Department of Gastroenterology and Hepatology, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, No. 60 Middle Qingnian Road, Nantong 226006, Jiangsu Province, China. bianzhaolian1998@163.com
Key Words Interleukin-34; Ulcerative colitis; Mucosal healing; Colitis-associated cancer; Macrophage; Murine model
Core Tip This study highlights the role of interleukin (IL)-34 in acute experimental colitis and wound healing phase in mice. We found that IL-34 did not drive inflammatory response and tissue destruction in physiological conditions, but protects the host from inflammatory injury and reduces the risk of colitis-associated cancer. IL-34 might serve as a potential therapeutic target for inducing mucosal healing in treatment of ulcerative colitis (UC) and reducing colitis-associated cancer in UC.
Citation Liu ZX, Chen WJ, Wang Y, Chen BQ, Liu YC, Cheng TC, Luo LL, Chen L, Ju LL, Liu Y, Li M, Feng N, Shao JG, Bian ZL. Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice. World J Gastroenterol 2022; In press
Received
2022-08-29 14:44
Peer-Review Started
2022-08-29 14:49
To Make the First Decision
Return for Revision
2022-10-20 19:40
Revised
2022-11-02 12:38
Second Decision
2022-11-22 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-11-23 02:41
Articles in Press
2022-11-23 02:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Yu-Lu Chen
Reviewer Code 04091933, and 03544596
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 79311_Auto_Edited-LM.docx
Answering Reviewers 79311-Answering reviewers.pdf
Audio Core Tip 79311-Audio core tip.m4a
Biostatistics Review Certificate 79311-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 79311-Conflict-of-interest statement.pdf
Copyright License Agreement 79311-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 79311-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 79311-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 79311-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 79311-Language certificate.pdf
Supplementary Material 79311-Supplementary material.pdf
Peer-review Report 79311-Peer-review(s).pdf
Scientific Misconduct Check 79311-Bing-Chen YL-2.png
Scientific Editor Work List 79311-Scientific editor work list.pdf