| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhao-Xiu Liu, Wei-Jie Chen, Yang Wang, Bing-Qian Chen, Yi-Cun Liu, Tiao-Chun Cheng, Lei-Lei Luo, Lin Chen, Lin-Ling Ju, Yuan Liu, Ming Li, Nan Feng, Jian-Guo Shao and Zhao-Lian Bian |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Bureau |
MS22018007 |
| Six peak talents in Jiangsu Province |
YY-177 |
| Project of Jiangsu Province Youth Medical Talent Development |
QNRC2016400, QNRC2016697 |
| Project of Nantong Youth Medical Talent Development |
No.05 |
| Youth Fund of National Natural Science Foundation of China |
82000497 |
| Youth Fund of Natural Science Foundation of Jiangsu Province |
BK20200965 |
| Scientific Research Fund of Nantong Health Commission |
MB2020037 |
|
| Corresponding Author |
Zhao-Lian Bian, MD, PhD, Associate Chief Physician, Associate Professor, Doctor, Department of Gastroenterology and Hepatology, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, No. 60 Middle Qingnian Road, Nantong 226006, Jiangsu Province, China. bianzhaolian1998@163.com |
| Key Words |
Interleukin-34; Ulcerative colitis; Mucosal healing; Colitis-associated cancer; Macrophage; Murine model |
| Core Tip |
This study highlights the role of interleukin (IL)-34 in acute experimental colitis and wound healing phase in mice. We found that IL-34 did not drive inflammatory response and tissue destruction in physiological conditions, but protects the host from inflammatory injury and reduces the risk of colitis-associated cancer. IL-34 might serve as a potential therapeutic target for inducing mucosal healing in treatment of ulcerative colitis (UC) and reducing colitis-associated cancer in UC. |
| Citation |
Liu ZX, Chen WJ, Wang Y, Chen BQ, Liu YC, Cheng TC, Luo LL, Chen L, Ju LL, Liu Y, Li M, Feng N, Shao JG, Bian ZL. Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice. World J Gastroenterol 2022; 28(47): 6752-6768 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
