Publication Name	World Journal of Orthopedics
Manuscript ID	79472
Country	Indonesia

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Mechanism of spinal cord injury regeneration and the effect of human neural stem cells-secretome treatment in rat model
Manuscript Source	Unsolicited Manuscript
All Author List	I Nyoman Semita, Dwikora Novembri Utomo and Heri Suroto
Funding Agency and Grant Number
Corresponding Author	Dwikora Novembri Utomo, MD, Surgeon, Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Airlangga, Manyar Tirtosari Street IV/7, Surabaya 60118, East Java, Indonesia. dwikora-novembri-u@fk.unair.ac.id
Key Words	Secretome; Regeneration mechanism; Spinal cord injury; Locomotor; Biomarkers
Core Tip	The human neural stem cell (HNSC)-secretomes is effective in spinal cord injury (SCI) treatment, based on locomotor function improvement, decreased size of spinal cord lesions, and biomarkers expression. Based on partial least squares structural equation modeling analysis, the regeneration mechanism of SCI started with pro-inflammation, anti-inflammation, anti-apoptotic, neuroangiogenesis, neurogenesis, finally, locomotor improvement.
Citation	Semita IN, Utomo DN, Suroto H. Mechanism of spinal cord injury regeneration and the effect of human neural stem cells-secretome treatment in rat model. World J Orthop 2023; 14(2): 64-82

Received	2022-09-01 03:47
Peer-Review Started	2022-09-01 03:52
To Make the First Decision
Return for Revision	2022-12-19 10:57
Revised	2022-12-22 07:42
Second Decision	2023-02-02 03:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-02 12:57
Articles in Press	2023-02-02 12:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-08 08:37

ISSN	2218-5836 (online)
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