Publication Name	World Journal of Hepatology
Manuscript ID	79672
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis
Manuscript Source	Invited Manuscript
All Author List	Sheng-Wei Li, Li-Fan Han, Yin He and Xiao-Sheng Wang
Funding Agency and Grant Number
Corresponding Author	Xiao-Sheng Wang, PhD, Associate Professor, Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing 211198, Jiangsu Province, China. xiaosheng.wang@cpu.edu.cn
Key Words	Hepatitis B virus; Hepatocellular carcinoma; Immunological classification; Transcriptomics; Tumor immunity; Cancer immunotherapy
Core Tip	First, for the first time, we identified immune-specific subtypes of hepatitis B virus (HBV) + hepatocellular carcinoma (HCC) based on immune signature scores and demonstrated that this new subtyping method was reproducible in three different datasets. Second, our subtyping method captures the comprehensive heterogeneity of HBV+ HCC in the tumor microenvironment, genomic integrity, protein expression profiles, DNA methylation profiles, tumor stemness, intratumor heterogeneity, and clinical outcomes. Third, our data suggest that it is copy number alterations but not tumor mutations responsible for the different immunity between the “hot” and “cold” tumor subtypes in HBV+ HCC. Finally, our identification of the immune-specific subtypes of HBV+ HCC may provide new insights into the tumor biology and identify the HBV+ HCC patients beneficial from immunotherapy.
Citation	Li SW, Han LF, He Y, Wang XS. Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis. World J Hepatol 2022; 14(12): 1997-2011

Received	2022-09-05 02:17
Peer-Review Started	2022-09-05 02:19
To Make the First Decision
Return for Revision	2022-09-30 08:58
Revised	2022-10-12 13:30
Second Decision	2022-11-22 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-11-23 06:08
Articles in Press	2022-11-23 06:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-30 01:08

ISSN	1948-5182 (online)
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