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11/23/2022 6:08:32 AM | Browse: 12 | Download: 3
Publication Name World Journal of Hepatology
Manuscript ID 79672
Country/Territory China
Category Oncology
Manuscript Type Basic Study
Article Title Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis
Manuscript Source Invited Manuscript
All Author List Sheng-Wei Li, Li-Fan Han, Yin He and Xiao-Sheng Wang
Funding Agency and Grant Number
Corresponding Author Xiao-Sheng Wang, PhD, Associate Professor, Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing 211198, Jiangsu Province, China. xiaosheng.wang@cpu.edu.cn
Key Words Hepatitis B virus; Hepatocellular carcinoma; Immunological classification; Transcriptomics; Tumor immunity; Cancer immunotherapy
Core Tip First, for the first time, we identified immune-specific subtypes of hepatitis B virus (HBV) + hepatocellular carcinoma (HCC) based on immune signature scores and demonstrated that this new subtyping method was reproducible in three different datasets. Second, our subtyping method captures the comprehensive heterogeneity of HBV+ HCC in the tumor microenvironment, genomic integrity, protein expression profiles, DNA methylation profiles, tumor stemness, intratumor heterogeneity, and clinical outcomes. Third, our data suggest that it is copy number alterations but not tumor mutations responsible for the different immunity between the “hot” and “cold” tumor subtypes in HBV+ HCC. Finally, our identification of the immune-specific subtypes of HBV+ HCC may provide new insights into the tumor biology and identify the HBV+ HCC patients beneficial from immunotherapy.
Citation Li SW, Han LF, He Y, Wang XS. Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis. World J Hepatol 2022; In press
Received
2022-09-05 02:17
Peer-Review Started
2022-09-05 02:19
To Make the First Decision
Return for Revision
2022-09-30 08:58
Revised
2022-10-12 13:30
Second Decision
2022-11-22 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-11-23 06:08
Articles in Press
2022-11-23 06:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ji-Hong Liu
Reviewer Code 00070191, and 06367185
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 79672_Auto_Edited-LM.docx
Answering Reviewers 79672-Answering reviewers.pdf
Audio Core Tip 79672-Audio core tip.m4a
Biostatistics Review Certificate 79672-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 79672-Conflict-of-interest statement.pdf
Copyright License Agreement 79672-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 79672-Language certificate.pdf
Supplementary Material 79672-Supplementary material.zip
Peer-review Report 79672-Peer-review(s).pdf
Scientific Misconduct Check 79672-Bing-Liu JH-2.jpg
Scientific Misconduct Check 79672-CrossCheck.jpg
Scientific Editor Work List 79672-Scientific editor work list.pdf