Publication Name	World Journal of Gastroenterology
Manuscript ID	79717
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19
Manuscript Source	Invited Manuscript
All Author List	Yang Yao, Zhu-Jun Liu, Yu-Kun Zhang and Hui-Jun Sun
Funding Agency and Grant Number	Funding Agency Grant Number Commission KJZD-K202002701 General Project of Chongqing Natural Science Foundation cstc2019jcyj msxmX0299 Key Project of Chongqing Three Gorges Medical College XJ2021000101 Chongqing Natural Drug Anti-Tumor Innovation Research Group CXQT20030 Special Fund for Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area Sys20210002 Open Project in 2022 of Chongqing Key Laboratory for the Development and Utilization of Authentic Medicinal Materials in the Three Gorges Reservoir Area KFKT2022004
Corresponding Author	Hui-Jun Sun, MMed, PhD, Professor, Researcher, Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, No. 9, West Section of Lushun South Road, Lvshunkou District, Dalian 116044, Liaoning Province, China. sunhuijun@dmu.edu.cn
Key Words	COVID-19; Angiotensin-converting enzyme-2; Transmembrane protease serine 2; Gastrointestinal symptom; Mechanism; Intestinal barrier permeability
Core Tip	Gastrointestinal symptoms in coronavirus disease 2019 patients have ranged from 12% to 61%, which include anorexia, nausea and/or vomiting, diarrhea, abdominal pain, and so on. However, the underlying mechanisms remain unclear. This study reviewed and discussed the correlated mechanisms that cause gastrointestinal symptoms in order to help to develop the treatment strategy and build an appropriate guideline for medical workers.
Citation	Yao Y, Liu ZJ, Zhang YK, Sun HJ. Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19. World J Gastroenterol 2022; 28(48): 6811-6826

Received	2022-09-09 16:03
Peer-Review Started	2022-09-09 16:06
To Make the First Decision
Return for Revision	2022-10-19 21:34
Revised	2022-11-01 15:51
Second Decision	2022-12-07 03:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-12-07 17:26
Articles in Press	2022-12-07 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-20 23:59

ISSN	1007-9327 (print) and 2219-2840 (online)
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