Publication Name	World Journal of Cardiology
Manuscript ID	79843
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	Early and aggressive presentation of wild-type transthyretin amyloid cardiomyopathy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ilham Boda, Hassan Farhoud, Tarun Dalia, Amandeep Goyal, Zubair Shah and Andrija Vidic
Funding Agency and Grant Number
Corresponding Author	Andrija Vidic, Consultant, N/A, N/A, Department of Cardiovascular Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, United States. avidic@kumc.edu
Key Words	Wild-type; Transthyretin; Amyloidosis; Young; Heart failure; Heart transplant; Case report
Core Tip	Wild-type transthyretin amyloidosis (ATTRwt) continues to be an underdiagnosed condition. Although rare in patients under 60 years of age, physicians should include the condition in their differential as early diagnosis and early management can impact patient outcomes. Physicians should be aware of the findings on non-invasive testing that supports ATTRwt. Classically on echocardiogram, cardiac amyloidosis can present as thickened ventricular walls, small lehigh valley chamber, biatrial enlargement, apical sparing on longitudinal strain and signs of elevated filling pressures and restrictive diastolic physiology (increased E/A ratio, E/e’ and reduced mitral annular tissue velocities). Cardiac magnetic resonance imaging classically shows late gadolinium enhancement. A technetium pyrophosphate study shows an increased heart-to-contralateral ratio and increased Perugini visual grade.
Citation	Boda I, Farhoud H, Dalia T, Goyal A, Shah Z, Vidic A. Early and aggressive presentation of wild-type transthyretin amyloid cardiomyopathy: A case report. World J Cardiol 2022; 14(12): 657-664

Received	2022-09-08 23:10
Peer-Review Started	2022-09-08 23:11
To Make the First Decision
Return for Revision	2022-10-13 01:20
Revised	2022-11-03 20:05
Second Decision	2022-11-18 04:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-11-23 03:00
Articles in Press	2022-11-23 03:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-30 07:36

ISSN	1949-8462 (online)
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