Publication Name	World Journal of Clinical Cases
Manuscript ID	79879
Country	China

Category	Clinical Neurology
Manuscript Type	Case Report
Article Title	Anti-leucine-rich glioma inactivated protein 1 encephalitis with sleep disturbance as the first symptom: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	De-Lian Kong
Funding Agency and Grant Number
Corresponding Author	De-Lian Kong, MD, PhD, Chief Doctor, Chief Physician, Department of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical University, No. 169 Hushan Road , Jiangning District, Nanjing 211000, Jiangsu Province, China. xykdl@163.com
Key Words	Leucine-rich glioma inactivated 1 antibody; Autoimmune encephalitis; Sleep disturbance; Seizures; Facio-brachial dystonic seizures; Case report
Core Tip	Anti-leucine-rich glioma inactivated protein 1 (anti-LGI1) encephalitis is a rare autoimmune encephalitis (AE) characterized by acute or subacute cognitive impairment, facio-brachial dystonic seizures, psychiatric disturbances and hyponatremia. Herein, we report that a male patient developed severe anti-LGI1 encephalitis, which was initially misdiagnosed as sleep disturbance. He had antibodies targeting LGI1 both in his cerebrospinal fluid and serum, which led to the diagnosis of typical anti-LGI1 AE. The case indicated that we should be aware of the possibility of LGI1 antibody-associated encephalitis to avoid missed diagnoses and misdiagnoses especially in adolescents with sleep disorders.
Citation	Kong DL. Anti-leucine-rich glioma inactivated protein 1 encephalitis with sleep disturbance as the first symptom: A case report and review of literature. World J Clin Cases 2023; 11(2): 408-416

Received	2022-09-10 10:59
Peer-Review Started	2022-09-10 11:01
To Make the First Decision
Return for Revision	2022-11-02 03:04
Revised	2022-11-20 13:35
Second Decision	2022-12-05 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-12-05 09:22
Articles in Press	2022-12-05 09:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-08 02:45

ISSN	2307-8960 (online)
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