Publication Name	World Journal of Hepatology
Manuscript ID	80145
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Recent advances in recurrent hepatocellular carcinoma therapy
Manuscript Source	Invited Manuscript
All Author List	Yu-Xue Gao, Qi-Qi Ning, Peng-Xiang Yang, Yuan-Yue Guan, Peng-Xiang Liu, Meng-Lu Liu, Lu-Xin Qiao, Xiang-Hua Guo, Tong-Wang Yang and De-Xi Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82073676 Chinesisch-Deutsches Forschungsprojekt in Sonderprogramm zu COVID-19 C-0012 Key Programs of Beijing Municipal Education Commission of China KZ202010025037 Third Round of Public Welfare Development and Reform Pilot Projects of Beijing Municipal Medical Research Institutes Jing 2019-6 Fourth Round of Public Welfare Development and Reform Pilot Projects of Beijing Municipal Medical Research Institutes Jing 2021-10
Corresponding Author	De-Xi Chen, PhD, Professor, Beijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, No. 8 Youanmenwai, Youanmen Street, Fengtai District, Beijing 100069, China. dexichen@ccmu.edu.cn
Key Words	Recurrent hepatocellular carcinoma; Liver transplantation; Therapy; Immunotherapy; Neoadjuvant and adjuvant therapy
Core Tip	Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, and up to 50%-70% of individuals may experience a relapse of the illness in the liver after 5 years. This review will provide novel approaches to improve the prognosis of patients with recurring HCC with the apparent lack of data to guide the clinical treatment. Neoadjuvant and/or adjuvant therapy methods potentially elevate the opportunity of cure in refractory patients with recurrent HCC and contribute to a better long-term prognosis.
Citation	Gao YX, Ning QQ, Yang PX, Guan YY, Liu PX, Liu ML, Qiao LX, Guo XH, Yang TW, Chen DX. Recent advances in recurrent hepatocellular carcinoma therapy. World J Hepatol 2023; 15(4): 460-476

Received	2022-09-19 00:10
Peer-Review Started	2022-09-19 00:12
To Make the First Decision
Return for Revision	2022-12-01 04:53
Revised	2022-12-20 06:34
Second Decision	2023-03-24 02:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-03-24 06:27
Articles in Press	2023-03-24 06:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-03-16 02:57
Typeset the Manuscript	2023-03-27 09:33

ISSN	1948-5182 (online)
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