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Publication Name World Journal of Clinical Pediatrics
Manuscript ID 80439
Country/Territory United Arab Emirates
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title COVID-19-induced liver injury in infants, children, and adolescents
Manuscript Source Invited Manuscript
All Author List Rana Bitar, Ahmed A Elghoudi, David Rawat, Amer Azaz, Mohamad Miqdady and Hassib Narchi
Funding Agency and Grant Number
Corresponding Author Ahmed A Elghoudi, MBChB, MSc, Adjunct Associate Professor, Doctor, Department of Pediatric, Sheikh Khalifa Medical City, Al Karama Street, Al Khalidya, Abu Dhabi N/A, United Arab Emirates. aelghoudi@seha.ae
Key Words Child; COVID-19; Gastroenterology; Hepatic dysfunction; Infection; Liver diseases; SARS-CoV-2; Liver injury; Liver transplant
Core Tip Liver injury presenting with elevated levels of alanine aminotransferase and aspartate aminotransferase is common in children infected with the coronavirus disease 2019 (COVID-19) virus. The mechanism of liver injury is not fully understood and is likely secondary to the viral invasion of the liver, hepato-toxic medications, and the patient’s own immune-mediated response. Liver injury in children is generally mild and resolves spontaneously but is usually seen in children with more severe illnesses. In addition, children with underlying non-alcoholic fatty liver disease or another chronic liver disease may have a higher risk of severe COVID-19 illness. Management of liver injury after COVID infection is supportive. Proactive vaccination may reduce the transmission of infection and the severity of the disease.
Citation Bitar R, Elghoudi AA, Rawat D, Azaz A, Miqdady M, Narchi H. COVID-19-induced liver injury in infants, children, and adolescents. World J Clin Pediatr 2023; In press
2022-09-29 14:42
Peer-Review Started
2022-09-27 19:55
To Make the First Decision
Return for Revision
2022-10-19 17:41
2022-11-07 17:00
Second Decision
2023-03-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-03-17 07:26
Articles in Press
2023-03-17 07:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Kai-Le Chang
Reviewer Code 05421264, 06333260, and 05421264
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor
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Responsible Production Editor
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Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma