Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	80439
Country	United Arab Emirates

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	COVID-19-induced liver injury in infants, children, and adolescents
Manuscript Source	Invited Manuscript
All Author List	Rana Bitar, Ahmed A Elghoudi, David Rawat, Amer Azaz, Mohamad Miqdady and Hassib Narchi
Funding Agency and Grant Number
Corresponding Author	Ahmed A Elghoudi, MBChB, MSc, Adjunct Associate Professor, Doctor, Department of Pediatric, Sheikh Khalifa Medical City, Al Karama Street, Al Khalidya, Abu Dhabi N/A, United Arab Emirates. aelghoudi@seha.ae
Key Words	Child; COVID-19; Gastroenterology; Hepatic dysfunction; Infection; Liver diseases; SARS-CoV-2; Liver injury; Liver transplant
Core Tip	Liver injury presenting with elevated levels of alanine aminotransferase and aspartate aminotransferase is common in children infected with the coronavirus disease 2019 (COVID-19) virus. The mechanism of liver injury is not fully understood and is likely secondary to the viral invasion of the liver, hepato-toxic medications, and the patient’s own immune-mediated response. Liver injury in children is generally mild and resolves spontaneously but is usually seen in children with more severe illnesses. In addition, children with underlying non-alcoholic fatty liver disease or another chronic liver disease may have a higher risk of severe COVID-19 illness. Management of liver injury after COVID infection is supportive. Proactive vaccination may reduce the transmission of infection and the severity of the disease.
Citation	Bitar R, Elghoudi AA, Rawat D, Azaz A, Miqdady M, Narchi H. COVID-19-induced liver injury in infants, children, and adolescents. World J Clin Pediatr 2023; 12(3): 57-67

Received	2022-09-29 14:42
Peer-Review Started	2022-09-27 19:55
To Make the First Decision
Return for Revision	2022-10-19 17:41
Revised	2022-11-07 17:00
Second Decision	2023-03-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-03-17 07:26
Articles in Press	2023-03-17 07:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-24 06:28

ISSN	2219-2808 (online)
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