Publication Name	World Journal of Gastroenterology
Manuscript ID	80502
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immunotherapy for hepatocellular carcinoma: Current status and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Deepa S Mandlik, Satish K Mandlik and Heena B Choudhary
Funding Agency and Grant Number
Corresponding Author	Deepa S Mandlik, PhD, Assistant Professor, Department of Pharmacology, BVDU, Poona College of Pharmacy, Kothrud, Pune 411038, Maharashtra, India. deepa.mandlik@bharatividyapeeth.edu
Key Words	Hepatocellular carcinoma; Immunotherapy; Immune checkpoint inhibitors; Alpha-fetoprotein; Cancer vaccine; Combination therapies
Core Tip	Core Tip: Hepatocellular carcinoma (HCC) is a multifaceted illness with multiple faces. It avoids early discovery, which provides the best chance of cure by resection/transplant, and systemic treatments are only of marginal efficacy at best, despite recent therapeutic advances. Current advances in immunotherapy and its combinations have altered the HCC treatment landscape, and clinical studies are continuing to pave the path forward. Immunotherapy increases survival rates and provides long-term cancer control in subsets of HCC patients while also minimising side effects. Further research into immunotherapy in combination with current treatments for HCC in the early and intermediate stages may assist a greater spectrum of patients. Continued research into programmed cell death 1/ programmed cell death ligand 1, TMB, ctDNA, microsatellite stability, DNA mismatch repair, neutrophil/lymphocyte ratio, cytokines, and cellular peripheral immune response will hopefully identify the most reliable marker for selecting and sequencing systemic treatments to achieve the best outcome in HCC patients. Despite such significant treatment advances in HCC, numerous hurdles remain. The scientific community must figure out how to appropriately sequence these medicines for the best potential response, how to control toxicities, and how to develop indicators to monitor for response and relapse.
Citation	Mandlik DS, Mandlik SK, Choudhary HB. Immunotherapy for hepatocellular carcinoma: Current status and future perspectives. World J Gastroenterol 2023; 29(6): 1054-1075

Received	2022-09-29 16:19
Peer-Review Started	2022-09-29 16:20
To Make the First Decision
Return for Revision	2022-12-12 08:16
Revised	2022-12-23 06:26
Second Decision	2023-01-20 03:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-01-20 23:48
Articles in Press	2023-01-20 23:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-27 17:59
Typeset the Manuscript	2023-01-30 07:07

ISSN	1007-9327 (print) and 2219-2840 (online)
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