Publication Name	World Journal of Gastroenterology
Manuscript ID	80548
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Iron as a therapeutic target in chronic liver disease
Manuscript Source	Invited Manuscript
All Author List	Elias Kouroumalis, Ioannis Tsomidis and Argyro Voumvouraki
Funding Agency and Grant Number
Corresponding Author	Elias Kouroumalis, MD, PhD, Emeritus Professor, Liver Research Laboratory, University of Crete Medical School, 13 Kalokerinou Street, Voutes, Heraklion 71003, Greece. kouroumi@uoc.gr
Key Words	Iron overload; Liver diseases; Ferroptosis; Ferritinophagy; Ferroptosis modulators
Core Tip	Iron overload may damage the liver in a variety of liver diseases such as cirrhosis and hepatocellular carcinoma affecting patient survival. In this review, we presented the evidence, both experimental and clinical, of the detrimental effects of iron deposition in hepatocytes and other liver sinusoidal cells. Moreover, we examined the mechanism and implications of the recently described ferroptosis in the evolution of liver diseases. Ferroptosis, is a form of regulated hepatocyte death caused by excess iron and lipid peroxidation. Inhibition or induction of ferroptosis may profoundly improve the natural course of many liver diseases as demonstrated by a large number of experimental studies and few clinical data.
Citation	Kouroumalis E, Tsomidis I, Voumvouraki A. Iron as a therapeutic target in chronic liver disease. World J Gastroenterol 2023; 29(4): 616-655

Received	2022-10-02 12:02
Peer-Review Started	2022-10-02 12:05
To Make the First Decision
Return for Revision	2022-10-29 00:20
Revised	2022-11-03 12:56
Second Decision	2022-12-30 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-12-31 05:58
Articles in Press	2022-12-31 05:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-08 00:43
Typeset the Manuscript	2023-01-12 08:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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