Publication Name	World Journal of Nephrology
Manuscript ID	80913
Country	Argentina

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Kidney stone matrix proteins: Their role in stone formation
Manuscript Source	Invited Manuscript
All Author List	Armando Luis Negri and Francisco Rodolfo Spivacow
Funding Agency and Grant Number
Corresponding Author	Armando Luis Negri, FACP, MD, Academic Editor, Professor, Department of Physiology and Biophysics, Instituto de Investigaciones Metabólicas, Libertad 836 1 Piso, Buenos Aires, 1012, Buenos Aires 1012, Argentina. negri@casasco.com.ar
Key Words	Stone formation; Kidney stone; matrix proteins; Uromodulin; Calgranulin; Proteomics
Core Tip	Several urinary proteins have been found in kidney stones matrix. In vitro and in vivo studies have shown that they have an important role in various process of calcium oxalate crystallization. Many of them have other functions in modulating oxidative stress, immune response and inflammation that could also influence stone formation. Yet, the exact role of these kidney stone matrix proteins  need to be established through more studies comparing urinary stone proteomics between stone formers and non-stone formers.
Citation	Negri AL, Spivacow FR. Kidney stone matrix proteins: Their role in stone formation. World J Nephrol 2023; 12(2): 21-28

Received	2022-10-18 13:19
Peer-Review Started	2022-10-18 13:21
To Make the First Decision
Return for Revision	2022-12-26 09:21
Revised	2023-01-18 18:28
Second Decision	2023-03-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-03-17 07:27
Articles in Press	2023-03-17 07:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-03-14 03:28
Typeset the Manuscript	2023-03-20 04:29

ISSN	2220-6124 (online)
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