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Publication Name World Journal of Hepatology
Manuscript ID 80986
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title COVID-19 and liver dysfunction in children: Current views and new hypotheses
Manuscript Source Invited Manuscript
All Author List Yang-Fang Yun, Zhi-Yuan Feng and Jing-Jing Zhang
Funding Agency and Grant Number
Corresponding Author Jing-Jing Zhang, Doctor, Professor, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, No. 163 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. jing15209791@nju.edu.cn
Key Words COVID-19; SARS-CoV-2; Children; Liver injury; Inflammatory immune response; Cytokine storm
Core Tip There are few cases of liver injury in children with Coronavirus disease 2019 (COVID-19) and clinical reports are scarce. We collected reports on COVID-19-related liver injury (CRLI) in children over the last two years and divided the etiology of CRLI into three categories: (1) the direct mechanism involves severe acute respiratory syndrome coronavirus 2 binding to angiotensin-converting enzyme 2 in the liver or bile duct to exert direct toxicity; (2) the indirect mechanisms include an inflammatory immune response and hypoxia; and (3) COVID-19-related treatments, such as mechanical ventilation and antiviral drugs, may cause liver injury. We also discuss the current controversies regarding the pathophysiology of CRLI.
Citation Yun YF, Feng ZY, Zhang JJ. COVID-19 and liver dysfunction in children: Current views and new hypotheses. World J Hepatol 2023; 15(3): 353-363
2022-10-28 02:52
Peer-Review Started
2022-10-28 02:54
To Make the First Decision
Return for Revision
2023-01-04 14:37
2023-01-14 15:01
Second Decision
2023-03-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-03-17 07:30
Articles in Press
2023-03-17 07:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-03-20 00:12
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Kai-Le Chang
Reviewer Code 03622345, 02536349, and 03622345
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor
Production Editor Yi-Xuan Cai
Responsible Production Editor Yi-Xuan Cai
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma