Publication Name	World Journal of Clinical Cases
Manuscript ID	81071
Country	China

Category	Emergency Medicine
Manuscript Type	Randomized Controlled Trial
Article Title	Ulinastatin in the treatment of severe acute pancreatitis: A single-center randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Su-Qin Wang, Wei Jiao, Jing Zhang, Ju-Fen Zhang, Yun-Na Tao, Qing Jiang and Feng Yu
Funding Agency and Grant Number	Funding Agency Grant Number Wuxi Science and Technology Development Fund WX03-02B0205-072001-10
Corresponding Author	Feng Yu, MM, Doctor, Doctor, Department of General Surgery, The 904th Hospital of Joint Logistic Support Force, No. 101 Xing Yuan North Road, Wuxi 214044, Jiangsu Province, China. yufeng904@21cn.com
Key Words	Ulinastatin; 7-day mortality; Severe acute pancreatitis; Randomized controlled trial; Outcome
Core Tip	One of the most prevalent gastrointestinal tract GI disorders, severe acute pancreatitis (AP), is the leading cause of hospitalization due to gastrointestinal diseases. The present study suggests that ulinastatin (UTI) can reduce the risk of overall 7-d mortality in severe AP patients and is associated with a higher total effective rate vs the placebo control group. We also found that UTI can protect against hyperinflammation. It also did not significantly increase the incidence rate of severe adverse effects.
Citation	Wang SQ, Jiao W, Zhang J, Zhang JF, Tao YN, Jiang Q, Yu F. Ulinastatin in the treatment of severe acute pancreatitis: A single-center randomized controlled trial. World J Clin Cases 2023; 11(19): 4601-4611

Received	2023-03-22 06:33
Peer-Review Started	2023-03-22 06:36
To Make the First Decision
Return for Revision	2023-05-13 03:16
Revised	2023-05-16 12:48
Second Decision	2023-06-02 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-06-02 08:03
Articles in Press	2023-06-02 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-25 01:50

ISSN	2307-8960 (online)
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