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1/20/2023 6:05:06 AM | Browse: 37 | Download: 48
Publication Name World Journal of Clinical Cases
Manuscript ID 81344
Country/Territory China
Category Urology and Nephrology
Manuscript Type Case Report
Article Title Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab: A case report
Manuscript Source Unsolicited Manuscript
All Author List Rui Yang, Jun-Xing Chen, Shu-Hang Luo, Ting-Ting Chen, Ling-Wu Chen and Bin Huang
Funding Agency and Grant Number
Corresponding Author Bin Huang, MD, PhD, Doctor, Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou 510080, Guangdong, China. huangb48@mail.sysu.edu.cn
Key Words Invasive urothelial carcinoma; Immunotherapy; Chemotherapy; Squamous and glandular differentiation; Tislelizumab; Case report
Core Tip Urothelial carcinoma (UC) with complicated differentiation is highly malignant, and radical cystectomy (RC) is the preferred treatment. Because of the complications related to RC, bladder-sparing therapy has become a research hotspot. We here report a patient who was diagnosed with muscle-invasive bladder cancer with squamous and glandular differentiation and positive programmed cell death-ligand 1 (PD-L1) expression. The patient received a combination of chemotherapy and immunotherapy and achieved bladder preservation and has maintained tumor-free for over two years. This case highlights that the combination treatment might be an effective and safe strategy for UC with divergent histologic differentiation and positive PD-L1 expression.
Citation Yang R, Chen JX, Luo SH, Chen TT, Chen LW, Huang B. Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab: A case report. World J Clin Cases 2023; In press
Received
2022-11-04 10:35
Peer-Review Started
2022-11-04 10:36
To Make the First Decision
Return for Revision
2022-12-13 08:53
Revised
2022-12-25 14:21
Second Decision
2023-01-20 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-01-20 06:05
Articles in Press
2023-01-20 06:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Li Li
Reviewer Code 02938533, and 05630677
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 81344_Auto_Edited-JLW.docx
Answering Reviewers 81344-Answering reviewers.pdf
Audio Core Tip 81344-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 81344-Conflict-of-interest statement.pdf
Copyright License Agreement 81344-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s) 81344-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 81344-Language certificate.pdf
Peer-review Report 81344-Peer-review(s).pdf
Scientific Misconduct Check 81344-Bing-Li L-2.png
Scientific Editor Work List 81344-Scientific editor work list.pdf