Publication Name	World Journal of Clinical Cases
Manuscript ID	81344
Country	China

Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Yang, Jun-Xing Chen, Shu-Hang Luo, Ting-Ting Chen, Ling-Wu Chen and Bin Huang
Funding Agency and Grant Number
Corresponding Author	Bin Huang, MD, PhD, Doctor, Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou 510080, Guangdong, China. huangb48@mail.sysu.edu.cn
Key Words	Invasive urothelial carcinoma; Immunotherapy; Chemotherapy; Squamous and glandular differentiation; Tislelizumab; Case report
Core Tip	Urothelial carcinoma (UC) with complicated differentiation is highly malignant, and radical cystectomy (RC) is the preferred treatment. Because of the complications related to RC, bladder-sparing therapy has become a research hotspot. We here report a patient who was diagnosed with muscle-invasive bladder cancer with squamous and glandular differentiation and positive programmed cell death-ligand 1 (PD-L1) expression. The patient received a combination of chemotherapy and immunotherapy and achieved bladder preservation and has maintained tumor-free for over two years. This case highlights that the combination treatment might be an effective and safe strategy for UC with divergent histologic differentiation and positive PD-L1 expression.
Citation	Yang R, Chen JX, Luo SH, Chen TT, Chen LW, Huang B. Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab: A case report. World J Clin Cases 2023; 11(5): 1165-1174

Received	2022-11-04 10:35
Peer-Review Started	2022-11-04 10:36
To Make the First Decision
Return for Revision	2022-12-13 08:53
Revised	2022-12-25 14:21
Second Decision	2023-01-20 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-20 06:05
Articles in Press	2023-01-20 06:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-03 07:55

ISSN	2307-8960 (online)
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