| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Postoperative jaundice related to UGT1A1 and ABCB11 gene mutations: A case report and literature review
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Lian Jiang, Xia Liu, Zhong-Qin Pan, Xiao-Ling Jiang, Jun-Hua Shi, Ya Chen, Yu Yi, Wei-Wei Zhong, Kang-Yan Liu and Yi-Huai He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
QKHJC-ZK[2022]YB642 |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
ZSKH·HZ(2022)344 |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
gzwjkj2021-071 |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
ZMC·YZ[2018]38 |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
ZSKH·HZ[2021]58 |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
ZSKH·HZ[2021]60 |
| General project of Hubei Province and Jingmen City |
2021YFYB074 |
|
| Corresponding Author |
Yi-Huai He, MD, Director, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. 993565989@qq.com |
| Key Words |
Cholestasis; Intrahepatic bile duct stones; Postoperative jaundice; adenosine triphosphate-binding cassette subfamily B member 11; Uridine 5’-diphospho-glucuronosyltransferase 1A1; Case report |
| Core Tip |
We presented a case of multiple intrahepatic bile duct stones, cholestasis, and progressive jaundice after surgical treatment, which was diagnosed upon the finding of adenosine triphosphate-binding cassette subfamily B member 11 (ABCB11) and uridine 5’-diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene mutation from the genetic study. Since the patient refused to undergo liver transplantation, his postoperative aggravating jaundice was medically managed, but he soon died due to liver failure. The UGT1A1 gene is related to the glucuronidation of indirect bilirubin. Its mutation leads to increased indirect bilirubin, while the ABCB11 gene is involved in bile transport, and its mutation may lead to disturbance of bile acid transport, changes in bile composition, cholestasis, and the formation of intrahepatic bile duct stones. Surgical treatment in such patients may induce exacerbation of cholestasis, and liver transplantation should be the preferred treatment if medical management fails. |
| Citation |
Jiang JL, Liu X, Pan ZQ, Jiang XL, Shi JH, Chen Y, Yi Y, Zhong WW, Liu KY, He YH. Postoperative jaundice related to UGT1A1 and ABCB11 gene mutations: A case report and literature review. World J Clin Cases 2023; 11(6): 1393-1402 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
