Publication Name	World Journal of Stem Cells
Manuscript ID	81509
Country	China

Category	Cell Biology
Manuscript Type	Review
Article Title	Adipokines regulate mesenchymal stem cell osteogenic differentiation
Manuscript Source	Invited Manuscript
All Author List	Zhong-Hua Xu, Chen-Wei Xiong, Kai-Song Miao, Zhen-Tang Yu, Jun-Jie Zhang, Chang-Lin Yu, Yong Huang and Xin-Die Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Changzhou Sci &Tech Program CJ20210104 Young Talent Development Plan of Changzhou Health Commission CZQM2020059 Top Talent of Changzhou “The 14th Five-Year Plan” High-Level Health Talents Training Project 2022CZBJ059 Qinghai Province Health System Guidance Plan Project 2022-wjzdx-106 Changzhou Sci &Tech Program CJ20220120 Changzhou Sci &Tech Program CJ20210005 Top Talent of Changzhou “The 14th Five-Year Plan” High-Level Health Talents Training Project 2022CZBJ061
Corresponding Author	Xin-Die Zhou, MD, Chief Doctor, Department of Orthopedics, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, No. 29 Xinglong Lane, Tianning District, Changzhou 213000, Jiangsu Province, China. zhouxindie@njmu.edu.cn
Key Words	Mesenchymal stem cell; Adipokine; Adipose tissue; Osteogenic differentiation; Osteogenesis; Bone regeneration
Core Tip	Bone tissue supports and protects the organs of the human body. There is a close relationship between the immune system and bone homeostasis. Adipose tissue is an essential accessory tissue around bone tissue, which regulates bone homeostasis through the secretion of adipocytokines. There are many types of adipokines, but only some have been studied in detail. Different adipokines affect the behavior and differentiation of mesenchymal stem cells under different local microenvironments and surrounding inflammation, thus coordinating and participating in the regulation of bone homeostasis.
Citation	Xu ZH, Xiong CW, Miao KS, Yu ZT, Zhang JJ, Yu CL, Huang Y, Zhou XD. Adipokine regulates mesenchymal stem cell osteogenic differentiation. World J Stem Cells 2023; 15(6): 502-513

Received	2022-11-14 02:06
Peer-Review Started	2022-11-14 02:08
To Make the First Decision
Return for Revision	2023-02-21 23:55
Revised	2023-02-26 13:48
Second Decision	2023-04-24 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-24 08:33
Articles in Press	2023-04-24 08:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-04-23 22:37
Typeset the Manuscript	2023-06-16 02:43

ISSN	1948-0210 (online)
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