Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	81632
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Evaluation of polygenic risk score for risk prediction of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Xiao-Yu Wang, Li-Li Wang, Lin Xu, Shu-Zhen Liang, Meng-Chao Yu, Qiu-Yue Zhang and Quan-Jiang Dong
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31870777
Corresponding Author	Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Central Laboratories and Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. allyking114@126.com
Key Words	Polygenic risk scores; Gastric cancer; Helicobacter pylori; Gastric microbiome
Core Tip	A systematic review was conducted to evaluate current polygenic risk score (PRS) models in gastric cancer risk prediction. Our study showed that PRS models had the potential to predict the risk of gastric cancer with a moderate accuracy. The prediction models’ performance could be improved after incorporating epidemiological factors or Helicobacter pylori (H. pylori) status. The potential of H. pylori genomic variations and members of the gastric microbiome were discussed as candidates for gastric cancer prediction models.
Citation	Wang XY, Wang LL, Xu L, Liang SZ, Yu MC, Zhang QY, Dong QJ. Evaluation of polygenic risk score for risk prediction of gastric cancer. World J Gastrointest Oncol 2023; 15(2): 276-285

Received	2022-11-18 02:19
Peer-Review Started	2022-11-18 02:21
To Make the First Decision
Return for Revision	2023-01-03 07:14
Revised	2023-01-11 13:19
Second Decision	2023-02-02 03:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-02 13:14
Articles in Press	2023-02-02 13:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-07 06:44

ISSN	1948-5204 (online)
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