Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	81765
Country	China

Category	Immunology
Manuscript Type	Basic Study
Article Title	Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development
Manuscript Source	Unsolicited Manuscript
All Author List	Tai-Liang Lu, Cheng-Long Li, Yong-Qiang Gong, Fu-Tao Hou and Chao-Wu Chen
Funding Agency and Grant Number
Corresponding Author	Chao-Wu Chen, MD, Chief Physician, Department of General Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 Jiefang Xi Road, Furong District, Changsha 410005, Hunan Province, China. dr.chencw@hunnu.edu.cn
Key Words	mRNA vaccine; Hepatocellular carcinoma; Immunotype; Antigens; Immune subtypes
Core Tip	In this study, bioinformatics methods were used to explore novel hepatocellular carcinoma (HCC)-specific antigens for mRNA vaccine development and construct an immune subtype of HCC to select the appropriate vaccination population. Tumor-specific antigens were defined as highly expressed, genetically altered, and prognostic genes associated with antigen-presenting cell infiltration. AURKA, CCNB1, CDC25C, CDK1, TRIP13, PES1, MCM3, PPM1G, NEK2, KIF2C, PTTG1, KPNA2, and PRC1 were recognized candidate HCC antigens for mRNA vaccine development. The IS1 and IS3 immune subtypes of HCC were suitable populations for mRNA vaccination. RBP4, KNG1, METTL7A, F12, and ABAT were potential biomarkers for mRNA vaccines.
Citation	Lu TL, Li CL, Gong YQ, Hou FT, Chen CW. Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development. World J Gastrointest Oncol 2023; 15(10): 1717-1738

Received	2023-06-13 15:42
Peer-Review Started	2023-06-13 15:44
To Make the First Decision
Return for Revision	2023-07-29 13:29
Revised	2023-08-10 15:30
Second Decision	2023-09-18 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-09-19 03:23
Articles in Press	2023-09-19 03:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-09-03 14:13
Typeset the Manuscript	2023-10-06 13:37

ISSN	1948-5204 (online)
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