Publication Name	World Journal of Stem Cells
Manuscript ID	81791
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts
Manuscript Source	Invited Manuscript
All Author List	Fang-Qi Li, Wen-Bo Chen, Zhi-Wen Luo, Yi-Sheng Chen, Ya-Ying Sun, Xiao-Ping Su, Jun-Ming Sun and Shi-Yi Chen
Funding Agency and Grant Number	Funding Agency Grant Number Sanming Project of Medicine in Shenzhen SZSM201612078 Health Shanghai Initiative Special Fund (Medical-Sports Integration, Creating a New Model of Exercise for Health) JKSHZX-2022-02
Corresponding Author	Shi-Yi Chen, Doctor, MD, PhD, Academic Editor, Academic Fellow, Chairman, Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Jing’an District, Shanghai 200040, China. cshiyi@163.com
Key Words	Exosome; MicroRNA; Fibroblast; Mesenchymal stem cell; Tendon-bone healing
Core Tip	Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) can activate fibroblasts and promote tendon-bone healing via the contained microRNAs (miRNAs). Supported by bioinformatics tools, this study identified two BMSC-derived exosomal miRNAs, has-miR-144-3p and has-miR-23b-3p, were overlapped in three GSE datasets. Bioinformatic analysis revealed that both miRNAs regulated the PI3K/Akt signaling pathway by targeting phosphatase and tensin homolog (PTEN). Experiments in vitro confirmed that interfering with PTEN can affect the phosphorylation of Akt and thus the activation of fibroblasts. These results suggested a potential mechanism by which BMSC-derived exosomes promote tendon-bone healing.
Citation	Li FQ, Chen WB, Luo ZW, Chen YS, Sun YY, Su XP, Sun JM, Chen SY. Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts. World J Stem Cells 2023; 15(4): 248-267

Received	2022-11-23 16:59
Peer-Review Started	2022-11-23 17:01
To Make the First Decision
Return for Revision	2023-01-06 18:22
Revised	2023-01-19 04:52
Second Decision	2023-03-03 03:35
Accepted by Journal Editor-in-Chief	2023-03-05 19:37
Accepted by Executive Editor-in-Chief	2023-03-23 09:47
Articles in Press	2023-03-23 09:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-18 04:24

ISSN	1948-0210 (online)
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