Publication Name	World Journal of Stem Cells
Manuscript ID	81896
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Obesity and cancer stem cells: Roles in cancer initiation, progression and therapy resistance
Manuscript Source	Invited Manuscript
All Author List	Wen-Jie Xie and Jian Li
Funding Agency and Grant Number
Corresponding Author	Jian Li, MM, Associate Chief Physician, Surgeon, Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, No. 190 East Section of Jiannan Road, Youxian District, Mianyang 621000, Sichuan Province, China. 654747973@qq.com
Key Words	Obesity; High-fat diet; Cancer stem cells; Carcinogenesis; Metastasis
Core Tip	Obesity increases the incidence and mortality of various cancers; however, research on how obesity affects cancer stem cells (CSCs) is still in its infancy. In this review, we discuss the association between obesity and CSCs, with a particular focus on how obesity promotes cancer initiation, progression and therapy resistance through CSCs and the mechanisms underlying these effects. In addition, the prospect of preventing cancer and targeting the mechanisms linking obesity and CSCs to reduce cancer risk or to improve the survival of patients with cancer is considered.
Citation	Xie WJ, Li J. Obesity and cancer stem cells: Roles in cancer initiation, progression and therapy resistance. World J Stem Cells 2023; 15(4): 120-135

Received	2022-11-28 08:32
Peer-Review Started	2022-11-28 08:34
To Make the First Decision
Return for Revision	2023-01-23 22:35
Revised	2023-01-28 02:14
Second Decision	2023-03-08 03:06
Accepted by Journal Editor-in-Chief	2023-03-09 05:36
Accepted by Executive Editor-in-Chief	2023-03-17 05:52
Articles in Press	2023-03-17 05:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-18 04:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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