Publication Name	World Journal of Stem Cells
Manuscript ID	82365
Country	Japan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes
Manuscript Source	Invited Manuscript
All Author List	Shuichiro Higo
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI 20K21602 JSPS KAKENHI 21H02915 JSPS KAKENHI 22K19526 the Japan Agency for Medical Research and Development 21bm0804008h0005 the Cell Science Research Foundation the Grant for Basic Research of the Japanese Circulation Society (2018) SENSHIN Medical Research Foundation
Corresponding Author	Shuichiro Higo, MD, PhD, Associate Professor, Department of Medical Therapeutics for Heart Failure, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. higo-s@cardiology.med.osaka-u.ac.jp
Key Words	Cardiomyopathy; Advanced heart failure; Induced pluripotent stem cell-derived cardiomyocytes; Desmosome; Genome editing; Gene therapy
Core Tip	Prevention of advanced heart failure caused by cardiomyopathy is an urgent unmet need in the field of cardiovascular medicine. Desmosome, a cell-to-cell junctional component, maintains the structural integrity of heart tissues. Genetic mutations in desmosomal genes cause desmosome-related cardiomyopathy, an intractable disease refractory to standard medical therapies. This review introduces the recent advances in disease modeling of desmosome-related cardiomyopathy caused by PKP2 mutations using induced pluripotent stem cell-derived cardiomyocytes.
Citation	Higo S. Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes. World J Stem Cells 2023; 15(3): 71-82

Received	2022-12-16 07:22
Peer-Review Started	2022-12-16 07:25
To Make the First Decision
Return for Revision	2023-02-03 18:21
Revised	2023-02-10 08:18
Second Decision	2023-03-08 03:07
Accepted by Journal Editor-in-Chief	2023-03-09 05:45
Accepted by Company Editor-in-Chief	2023-03-17 05:46
Articles in Press	2023-03-17 05:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-03-20 01:53

ISSN	1948-0210 (online)
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