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3/17/2023 5:46:56 AM | Browse: 44 | Download: 0
Publication Name World Journal of Stem Cells
Manuscript ID 82365
Country Japan
Category Cardiac & Cardiovascular Systems
Manuscript Type Minireviews
Article Title Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes
Manuscript Source Invited Manuscript
All Author List Shuichiro Higo
Funding Agency and Grant Number
Funding Agency Grant Number
the Japan Agency for Medical Research and Development 21bm0804008h0005
the Cell Science Research Foundation
the Grant for Basic Research of the Japanese Circulation Society (2018)
SENSHIN Medical Research Foundation
Corresponding Author Shuichiro Higo, MD, PhD, Associate Professor, Department of Medical Therapeutics for Heart Failure, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. higo-s@cardiology.med.osaka-u.ac.jp
Key Words Cardiomyopathy; Advanced heart failure; Induced pluripotent stem cell-derived cardiomyocytes; Desmosome; Genome editing; Gene therapy
Core Tip Prevention of advanced heart failure caused by cardiomyopathy is an urgent unmet need in the field of cardiovascular medicine. Desmosome, a cell-to-cell junctional component, maintains the structural integrity of heart tissues. Genetic mutations in desmosomal genes cause desmosome-related cardiomyopathy, an intractable disease refractory to standard medical therapies. This review introduces the recent advances in disease modeling of desmosome-related cardiomyopathy caused by PKP2 mutations using induced pluripotent stem cell-derived cardiomyocytes.
Citation Higo S. Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes. World J Stem Cells 2023; 15(3): 71-82
2022-12-16 07:22
Peer-Review Started
2022-12-16 07:25
To Make the First Decision
Return for Revision
2023-02-03 18:21
2023-02-10 08:18
Second Decision
2023-03-08 03:07
Accepted by Journal Editor-in-Chief
2023-03-09 05:45
Accepted by Company Editor-in-Chief
2023-03-17 05:46
Articles in Press
2023-03-17 05:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-03-20 01:53
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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