Publication Name	World Journal of Virology
Manuscript ID	82892
Country	Brazil

Category	Virology
Manuscript Type	Minireviews
Article Title	Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management
Manuscript Source	Invited Manuscript
All Author List	Marcel Silva Luz, Fabian Fellipe Bueno Lemos, Samuel Luca Rocha Pinheiro, Hanna Santos Marques, Luís Guilherme de Oliveira Silva, Mariana Santos Calmon, Karolaine da Costa Evangelista and Fabrício Freire de Melo
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Initiation Scholarship Programme (PIBIC) of the National Council for Scientific and Technological Development, CNPq, Brazil CNPq Research Productivity Fellow (PQ)
Corresponding Author	Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Key Words	Pediatric multisystem inflammatory disease; COVID-19 related; Multisystem inflammatory syndrome in children; COVID-19; SARS-CoV-2; Etiology; Disease management
Core Tip	Multisystem inflammatory syndrome in children (MIS-C) comprises a severe and out-of-control inflammatory response with multiorgan dysfunction following severe acute respiratory syndrome coronavirus 2 infection. Despite its severity, there are no definitive disease management guidelines for this condition. Conversely, the complex pathogenesis of MIS-C is still not completely understood, although it seems to rely upon immune dysregulation. Hence, in this study, we aim to bring together current evidence regarding the pathogenic mechanisms of MIS-C, clinical picture and management, in order to provide insights for clinical practice and implications for future research directions.
Citation	Silva Luz M, Lemos FFB, Rocha Pinheiro SL, Marques HS, de Oliveira Silva LG, Calmon MS, da Costa Evangelista K, Freire de Melo F. Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management. World J Virol 2023; 12(3): 193-203

Received	2022-12-29 03:02
Peer-Review Started	2022-12-29 03:03
To Make the First Decision
Return for Revision	2023-04-13 07:58
Revised	2023-04-28 01:46
Second Decision	2023-05-24 02:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-05-24 08:04
Articles in Press	2023-05-24 08:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-16 08:07

ISSN	2220-3249 (online)
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