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5/24/2023 8:04:55 AM | Browse: 42 | Download: 0
Publication Name World Journal of Virology
Manuscript ID 82892
Country Brazil
Category Virology
Manuscript Type Minireviews
Article Title Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management
Manuscript Source Invited Manuscript
All Author List Marcel Silva Luz, Fabian Fellipe Bueno Lemos, Samuel Luca Rocha Pinheiro, Hanna Santos Marques, Luís Guilherme de Oliveira Silva, Mariana Santos Calmon, Karolaine da Costa Evangelista and Fabrício Freire de Melo
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Initiation Scholarship Programme (PIBIC) of the National Council for Scientific and Technological Development, CNPq, Brazil
CNPq Research Productivity Fellow (PQ)
Corresponding Author Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Key Words Pediatric multisystem inflammatory disease; COVID-19 related; Multisystem inflammatory syndrome in children; COVID-19; SARS-CoV-2; Etiology; Disease management
Core Tip Multisystem inflammatory syndrome in children (MIS-C) comprises a severe and out-of-control inflammatory response with multiorgan dysfunction following severe acute respiratory syndrome coronavirus 2 infection. Despite its severity, there are no definitive disease management guidelines for this condition. Conversely, the complex pathogenesis of MIS-C is still not completely understood, although it seems to rely upon immune dysregulation. Hence, in this study, we aim to bring together current evidence regarding the pathogenic mechanisms of MIS-C, clinical picture and management, in order to provide insights for clinical practice and implications for future research directions.
Citation Silva Luz M, Lemos FFB, Rocha Pinheiro SL, Marques HS, de Oliveira Silva LG, Calmon MS, da Costa Evangelista K, Freire de Melo F. Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management. World J Virol 2023; 12(3): 193-203
2022-12-29 03:02
Peer-Review Started
2022-12-29 03:03
To Make the First Decision
Return for Revision
2023-04-13 07:58
2023-04-28 01:46
Second Decision
2023-05-24 02:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-24 08:04
Articles in Press
2023-05-24 08:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-06-16 08:07
ISSN 2220-3249 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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