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Publication Name World Journal of Gastroenterology
Manuscript ID 84581
Country United Kingdom
Category Oncology
Manuscript Type Retrospective Cohort Study
Article Title Regional variation in routes to diagnosis of cholangiocarcinoma in England from 2006 to 2017
Manuscript Source Unsolicited Manuscript
All Author List Amy Zalin-Miller, Sophie Jose, Craig Knott, Lizz Paley, Daniela Tataru, Helen Morement, Mireille B Toledano and Shahid A Khan
Funding Agency and Grant Number
Funding Agency Grant Number
AMMF – The Cholangiocarcinoma Charity
Corresponding Author Amy Zalin-Miller, MSc, Senior Researcher, Department of Analytics, Health Data Insight CIC, Capital Park, Fulbourn, Cambridge CB21 5XE, United Kingdom. amy.zalin@nhs.net
Key Words Cholangiocarcinoma; Route to diagnosis; Two week wait; Emergency presentation; Regional variation
Core Tip We investigated changes to routes to diagnosis for cholangiocarcinoma patients across England’s 21 regional Cancer Alliances over a 12-year period, and factors associated with differences. We found almost half (49.6%) of 22632 patients in the study were diagnosed via Emergency Presentation, a route associated with late presentation, advanced disease and poorer outcomes. Those diagnosed by Two week wait referral through a primary care doctor, where earlier diagnoses are possible, increased from 9.8-19.8% from 2006-2017, still considered low. Significant regional variation was found, alongside the discovery that age, comorbidities and underlying liver disease had independent associations with their routes to diagnosis.
Citation Zalin-Miller A, Jose S, Knott C, Paley L, Tataru D, Morement H, Toledano MB, Khan SA. Regional variation in routes to diagnosis of cholangiocarcinoma in England from 2006 to 2017. World J Gastroenterol 2023; 29(24): 3825-3842
2023-03-20 13:55
Peer-Review Started
2023-03-20 13:58
To Make the First Decision
Return for Revision
2023-04-27 05:08
2023-05-05 21:38
Second Decision
2023-05-25 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-25 09:12
Articles in Press
2023-05-25 09:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-06-13 13:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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