Publication Name	World Journal of Gastroenterology
Manuscript ID	84682
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription-3
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Yang, Yi Nan, Yu-Hua Du, Shi-Cong Huang, Dou-Dou Lu, Jun-Fei Zhang, Xia Li, Yan Chen, Lei Zhang and Ling Yuan
Funding Agency and Grant Number	Funding Agency Grant Number Ningxia Medical University Project XZ2021005 Ningxia Natural Science Foundation 2022AAC03144, 2022AAC02039 National Natural Science Foundation of China 82260879
Corresponding Author	Ling Yuan, MD, PhD, Professor, N/A, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. nxykdx@qq.com
Key Words	18β-Glycyrrhetinic acid; miR-328-3p; Signal transducer and activator of transcription 3; Cell proliferation; Autophagy flow
Core Tip	18β-glycyrrhetinic acid (18β-GRA) is an important bioactive component of glycyrrhiza liquorice. Our results showed that 18β-GRA up-regulates the expression of miR-328-3p in gastric cancer (GC) cell. Overexpression of miR-328-3p inhibits GC cell proliferation and colony formation, arrests the cell cycle, promotes apoptosis, inhibits subcutaneous tumor formation, and signal transducer and activator of transcription 3 (STAT3) expression. Dual-luciferase reporter assay showed that miR-328-3p could target the regulation of STAT3. The study of monomeric Red Fluorescent Protein-green fluorescent protein-light chain 3 double-labeled adenovirus and western blot indicated that 18β-GRA promotes autophagy flow by promoting autophagosome synthesis. These data suggest that 18β-GRA promotes cell autophagy and inhibits the proliferation of GC cell by regulating miR-328-3p/STAT3.
Citation	Yang Y, Nan Y, Du YH, Huang SC, Lu DD, Zhang JF, Li X, Chen Y, Zhang L, Yuan L. 18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription-3. World J Gastroenterol 2023;29(27): 4317-4333

Received	2023-03-28 09:50
Peer-Review Started	2023-03-28 09:54
To Make the First Decision
Return for Revision	2023-04-27 04:34
Revised	2023-05-10 14:52
Second Decision	2023-06-02 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-06-02 08:11
Articles in Press	2023-06-02 08:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-06-29 02:47
Typeset the Manuscript	2023-07-10 06:23

ISSN	1007-9327 (print) and 2219-2840 (online)
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