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Publication Name World Journal of Gastroenterology
Manuscript ID 84682
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title 18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription-3
Manuscript Source Unsolicited Manuscript
All Author List Yi Yang, Yi Nan, Yu-Hua Du, Shi-Cong Huang, Dou-Dou Lu, Jun-Fei Zhang, Xia Li, Yan Chen, Lei Zhang and Ling Yuan
Funding Agency and Grant Number
Funding Agency Grant Number
Ningxia Medical University Project XZ2021005
Ningxia Natural Science Foundation 2022AAC03144, 2022AAC02039
National Natural Science Foundation of China 82260879
Corresponding Author Ling Yuan, MD, PhD, Professor, N/A, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. nxykdx@qq.com
Key Words 18β-Glycyrrhetinic acid; miR-328-3p; Signal transducer and activator of transcription 3; Cell proliferation; Autophagy flow
Core Tip 18β-glycyrrhetinic acid (18β-GRA) is an important bioactive component of glycyrrhiza liquorice. Our results showed that 18β-GRA up-regulates the expression of miR-328-3p in gastric cancer (GC) cell. Overexpression of miR-328-3p inhibits GC cell proliferation and colony formation, arrests the cell cycle, promotes apoptosis, inhibits subcutaneous tumor formation, and signal transducer and activator of transcription 3 (STAT3) expression. Dual-luciferase reporter assay showed that miR-328-3p could target the regulation of STAT3. The study of monomeric Red Fluorescent Protein-green fluorescent protein-light chain 3 double-labeled adenovirus and western blot indicated that 18β-GRA promotes autophagy flow by promoting autophagosome synthesis. These data suggest that 18β-GRA promotes cell autophagy and inhibits the proliferation of GC cell by regulating miR-328-3p/STAT3.
Citation Yang Y, Nan Y, Du YH, Huang SC, Lu DD, Zhang JF, Li X, Chen Y, Zhang L, Yuan L. 18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription-3. World J Gastroenterol 2023;29(27): 4317-4333
Received
2023-03-28 09:50
Peer-Review Started
2023-03-28 09:54
To Make the First Decision
Return for Revision
2023-04-27 04:34
Revised
2023-05-10 14:52
Second Decision
2023-06-02 03:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-06-02 08:11
Articles in Press
2023-06-02 08:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-06-29 02:47
Typeset the Manuscript
2023-07-10 06:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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