Publication Name	World Journal of Gastroenterology
Manuscript ID	84685
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy
Manuscript Source	Invited Manuscript
All Author List	Yun Jin, Ying-Hao Guo, Jia-Cheng Li, Qi Li, Dan Ye, Xiao-Xiao Zhang and Jiang-Tao Li
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province LQ21H030005
Corresponding Author	Jiang-Tao Li, FACS, MD, Chief Doctor, Professor, Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zrljt@zju.edu.cn
Key Words	Liver regeneration; Vascular endothelial growth factor; Nano materials; Liver resection
Core Tip	Low regenerative ability of the liver remaining after partial hepatectomy may lead to serious complications including liver failure. The proliferation of liver sinusoidal endothelial cells (LSECs) is slower and occurs later compared to that of hepatocytes, leading to a delayed recovery of the hepatic sinusoids and impaired liver regeneration. Hepatocytes secrete vascular endothelial growth factor (VEGF) that promotes the proliferation of LSECs, and supplementation of exogenous VEGF after hepatectomy also increases the number of LSECs in the remaining liver, thus promoting the reestablishment of the hepatic sinusoids and accelerating liver regeneration. This review summarized the most recent findings on liver regeneration and new strategies for the localized delivery in the liver.
Citation	Jin Y, Guo YH, Li JC, Li Q, Ye D, Zhang XX, Li JT. Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy. World J Gastroenterol 2023; 29(24): 3748-3757

Received	2023-04-03 05:06
Peer-Review Started	2023-04-03 05:08
To Make the First Decision
Return for Revision	2023-05-04 22:14
Revised	2023-05-13 04:27
Second Decision	2023-06-02 03:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-06-02 09:03
Articles in Press	2023-06-02 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-15 08:50

ISSN	1007-9327 (print) and 2219-2840 (online)
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