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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 84710
Country/Territory China
Category Oncology
Manuscript Type Case Control Study
Article Title Proteomics-based identification of proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Ge-Yu-Jia Zhou, Dong-Yan Zhao, Teng-Fei Yin, Qian-Qian Wang, Yuan-Chen Zhou and Shu-Kun Yao
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Development Plan for Precision Medicine Research 2017YFC0910002
Corresponding Author Shu-Kun Yao, Doctor, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words Exosomes; Colorectal cancer; Data-independent acquisition; Parallel reaction monitoring; Biomarker
Core Tip We innovatively combined high-throughput quantitative proteomics analysis with colorectal cancer (CRC) tissue-originated exosomes. The comprehensive proteomic signature of CRC tissue exosomes was described using data-independent acquisition mass spectrometry, which revealed a mass of differentially expressed exosomal proteins. Six promising exosomal proteins, NHP2, OLFM4, TOP1, SAMP, TAGL and TRIM28, were verified by parallel reaction monitoring analysis and receiver operating characteristic curve analysis. The results indicated that these exosomal proteins could become potential diagnostic markers and effective therapeutic targets for CRC.
Citation Zhou GYJ, Zhao DY, Yin TF, Wang QQ, Zhou YC, Yao SK. Proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer revealed by proteomics. World J Gastrointest Oncol 2023; In press
Received
2023-03-26 02:23
Peer-Review Started
2023-03-26 02:26
To Make the First Decision
Return for Revision
2023-04-18 02:57
Revised
2023-04-28 23:05
Second Decision
2023-05-25 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-25 09:19
Articles in Press
2023-05-25 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 03004840
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma