Publication Name	World Journal of Gastroenterology
Manuscript ID	84966
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Zhi Qu, Luan Wang, Juan-Juan Chen and Yang Wang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Liaoning Province 2020-MS-148
Corresponding Author	Yang Wang, MD, PhD, Associate Professor, Doctor, Department of General Surgery, The 4th Affiliated Hospital of China Medical University, No.4 Chongshan Road, Huanggu District, Shenyang 110032, Liaoning Province, China. wwyy840731@126.com
Key Words	Raf kinase inhibitory protein; Phosphorylated extracellular-signal-regulated kinase; Gastrointestinal stromal tumors; Immunohistochemistry; Survival analysis; Risk grade model
Core Tip	Nowadays, research reports on the expression of downstream proteins of the Extracellular Signal-Regulated Kinase (ERK)/Mitogen-activated protein kinase pathway combined with Raf Kinase Inhibitor Protein (RKIP) in gastrointestinal stromal tumor (GIST) is scarce. This study will focus on this aspect and use immunohistochemistry methods, large sample survival analysis data, and the latest bioinformatics analysis techniques to answer the problem. Our experimental results showed that the expression of the two proteins had a certain negative correlation. The combined expression of RKIP and p-ERK proteins can serve as an independent risk factor for predicting the prognosis of GIST patients. Furthermore, the new risk assessment model incorporating RKIP and p-ERK has superior evaluation efficacy.
Citation	Qu WZ, Wang L, Chen JJ, Wang Y. Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor. World J Gastroenterol 2023; 29(26): 4200-4213

Received	2023-04-24 08:00
Peer-Review Started	2023-04-24 08:00
To Make the First Decision
Return for Revision	2023-05-16 02:33
Revised	2023-05-20 03:17
Second Decision	2023-06-02 03:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-06-02 08:18
Articles in Press	2023-06-02 08:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-06-10 20:16
Typeset the Manuscript	2023-06-24 07:04

ISSN	1007-9327 (print) and 2219-2840 (online)
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