Publication Name	World Journal of Gastroenterology
Manuscript ID	84988
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Effect of lifestyle modification on hepatocellular carcinoma incidence and mortality among patients with chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Yewan Park, Danbee Kang, Dong Hyun Sinn, Hyunsoo Kim, Yun Soo Hong, Juhee Cho and Geum-Youn Gwak
Funding Agency and Grant Number
Corresponding Author	Danbee Kang, PhD, Professor, Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 25-2 Sungkyunkwan-ro, Jongno-gu, Seoul 06355, South Korea. dbee.kang@gmail.com
Key Words	Lifestyle modification; Chronic hepatitis B; Hepatocellular carcinoma; Cancer; Mortality
Core Tip	Unhealthy behaviors, including smoking, sedentary lifestyle, or alcohol drinking, are known to have adverse effect on the outcome among chronic hepatitis B (CHB) patients. However, there are limited data on the effect of healthier lifestyle modification (LSM), including quitting smoking, regular exercise, and quitting drinking, on the risk of hepatocellular carcinoma (HCC) in CHB patients. In this first hypothetical randomized trial, we demonstrated that the LSM lowers the risk of developing HCC by using the nationwide database. The findings of this study highlight the necessity for active counseling and therapeutic intervention for LSM in CHB patients.
Citation	Park Y, Kang D, Sinn DH, Kim H, Hong YS, Cho J, Gwak GY. Effect of lifestyle modification on hepatocellular carcinoma incidence and mortality among patients with chronic hepatitis B. World J Gastroenterol 2023; 29(24): 3843-3854

Received	2023-04-10 14:52
Peer-Review Started	2023-04-10 14:54
To Make the First Decision
Return for Revision	2023-04-28 04:24
Revised	2023-05-13 00:11
Second Decision	2023-05-24 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-05-25 16:42
Articles in Press	2023-05-25 16:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-15 08:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com