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Publication Name World Journal of Psychiatry
Manuscript ID 85061
Country/Territory China
Category Psychiatry
Manuscript Type Case Control Study
Article Title Glutamate decarboxylase 1 gene polymorphisms are associated with respiratory symptoms in panic disorder
Manuscript Source Unsolicited Manuscript
All Author List Zhi-Li Zou, Jian Qiu, Xiao-Bo Zhou, Yu-Lan Huang, Jin-Yu Wang, Bo Zhou and Yuan Zhang
Funding Agency and Grant Number
Corresponding Author Yuan Zhang, MS, Assistant Professor, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 32 West Second Section First Ring Road, Chengdu 610072, Sichuan Province, China. 447415054@qq.com
Key Words Panic disorder; Gene polymorphisms; Respiratory symptoms; Allele frequencies; Pathogenesis; Chinese population
Core Tip The study found that the A/A genotype of glutamate decarboxylase 1 (GAD1) rs1978340 was associated with increased severity of respiratory symptoms in patients with panic disorder (PD). However, there were no significant differences between cases and controls in the genotype distributions or allele frequencies of GAD1 (rs1978340 and rs3749034), and neither did GAD1 (rs1978340 and rs3749034) have a significant effect on the severity of PD symptoms. These findings suggest that genetic factors may play a role in the pathogenesis of PD, particularly in respiratory symptoms, but further studies with larger sample sizes are needed to confirm these results.
Citation Zou ZL, Qiu J, Zhou XB, Huang YL, Wang JY, Zhou B, Zhang Y. Glutamate decarboxylase 1 gene polymorphisms are associated with respiratory symptoms in panic disorder. World J Psychiatry 2023; 13(7): 435-443
Received
2023-04-12 03:36
Peer-Review Started
2023-04-12 03:38
To Make the First Decision
Return for Revision
2023-05-12 01:58
Revised
2023-05-18 06:57
Second Decision
2023-05-31 03:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-31 19:02
Articles in Press
2023-05-31 19:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-06-20 08:30
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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