Publication Name	World Journal of Gastroenterology
Manuscript ID	85199
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment
Manuscript Source	Invited Manuscript
All Author List	Kai-Yue Huang, Feng-Yun Wang, Mi Lv, Xiang-Xue Ma, Xu-Dong Tang and Lin Lv
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81873297 the Fundamental Research Funds for the Central Public Welfare Research Institutes, China ZZ13-YQ-006 Innovation Fund of Chinese Academy of Chinese Medical Sciences, China CI2021A01003
Corresponding Author	Lin Lv, MD, Associate Chief Physician, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. lushangshitou@qq.com
Key Words	Irritable bowel syndrome; Overlap; Pathophysiology; Treatment
Core Tip	Irritable bowel syndrome (IBS) is a physical and mental illness that is becoming more prevalent, and its impact on society is expanding. Understanding of IBS has changed since the release of the Rome IV diagnosis in 2016, and this paper reviews the literature from the past decade to find that research around the brain-gut axis, diet, and gut microbiota are at the forefront of IBS. Moreover, as the research on the physiopathology of IBS has advanced, the treatment model has become more refined, which has important clinical implications.
Citation	Huang KY, Wang FY, Lv M, Ma XX, Tang XD, Lv L. Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment. World J Gastroenterol 2023; 29(26): 4120-4135

Received	2023-04-17 08:21
Peer-Review Started	2023-04-17 08:23
To Make the First Decision
Return for Revision	2023-05-12 02:45
Revised	2023-05-19 01:11
Second Decision	2023-06-08 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-06-11 23:46
Articles in Press	2023-06-11 23:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-25 01:03

ISSN	1007-9327 (print) and 2219-2840 (online)
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