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5/25/2023 9:03:52 AM | Browse: 42 | Download: 0
Publication Name World Journal of Clinical Cases
Manuscript ID 85554
Country China
Category Medicine, General & Internal
Manuscript Type Observational Study
Article Title Network pharmacology and molecular docking to explore Polygoni Cuspidati Rhizoma et Radix treatment for acute lung injury
Manuscript Source Unsolicited Manuscript
All Author List Jia-Lin Zheng, Xiao Wang, Zhe Song, Peng Zhou, Gui-Ju Zhang, Juan-Juan Diao, Cheng-En Han, Guang-Yuan Jia, Xu Zhou and Bao-Qing Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
Shandong Province Integrated Traditional Chinese and Western Medicine Professional Disease Prevention and Control Project YXH2019ZXY010
Corresponding Author Bao-Qing Zhang, MD, Attending Doctor, Department of Respiratory, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 42 Wenhua West Road, Jinan City, Jinan 250014, Shandong Province, China. mihuai8556@126.com
Key Words Traditional Chinese medicine; Acute lung injury; Infections; Database; Network pharmacology; Molecular docking
Core Tip This study used network pharmacology and molecular docking to explore the treatment of acute lung injury (ALI) using Polygoni Cuspidati Rhizoma et Radix (PCRR), a traditional Chinese medicine (TCM). Functional enrichment analysis suggested that PCRR alleviated ALI symptoms by modulating multiple pathways, including inflammation, immune modulation, and drug metabolism. We identified 13 bioactive compounds and 60 therapeutically relevant genes. Molecular docking further confirmed the strong association between the active ingredients and core targets. This study provides insights into the mechanisms of TCM at the network pharmacology level for the treatment of ALI.
Citation Zheng JL, Wang X, Song Z, Zhou P, Zhang GJ, Diao JJ, Han CE, Jia GY, Zhou X, Zhang BQ. Network pharmacology and molecular docking to explore Polygoni Cuspidati Rhizoma et Radix treatment for acute lung injury. World J Clin Cases 2023; 11(19): 4579-4600
2023-05-04 08:56
Peer-Review Started
2023-05-04 08:56
To Make the First Decision
Return for Revision
2023-05-12 01:28
2023-05-15 04:32
Second Decision
2023-05-25 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-25 09:03
Articles in Press
2023-05-25 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-06-25 01:18
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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