Publication Name	World Journal of Clinical Cases
Manuscript ID	85584
Country	South Korea

Category	Hematology
Manuscript Type	Case Report
Article Title	T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Sungwoo Park, Eun Jeong Jeong, Jung Hun Kang, Gyeong-Won Lee, Se-Il Go, Dong-Hyun Lee and Eun-Ha Koh
Funding Agency and Grant Number
Corresponding Author	Gyeong-Won Lee, MD, PhD, Associate Professor, Division of Hematology and Oncology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 52727, South Korea. brightree@naver.com
Key Words	Mixed-phenotype acute leukemia; Venetoclax; Decitabine; Case report
Core Tip	We report a 55-year-old male diagnosed with T/myeloid mixed-phenotype acute leukemia (MPAL) who received induction chemotherapy with vincristine, prednisolone, daunorubicin, and L-asparaginase. The patient experienced septic shock 10 days post-induction therapy and received antibiotic therapy to treat extended-spectrum beta-lactamase-positive bacteremia. Bone marrow examination post-sepsis recovery revealed refractory disease. To reduce the infection risk, venetoclax and decitabine were administered as chemotherapy-free induction therapy. After two additional venetoclax/decitabine cycles, the patient underwent haploidentical peripheral blood stem-cell transplantation, subsequently achieving complete response. This is the third report documenting the successful treatment of refractory T/myeloid MPAL with venetoclax and a hypomethylating agent.
Citation	Park S, Jeong EJ, Kang JH, Lee GW, Go SI, Lee DH, Koh EH. T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine: A case report. World J Clin Cases 2023; 11(26): 6200-6205

Received	2023-05-25 04:37
Peer-Review Started	2023-05-25 04:38
To Make the First Decision
Return for Revision	2023-06-15 09:16
Revised	2023-07-24 12:40
Second Decision	2023-08-18 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-08-18 09:04
Articles in Press	2023-08-18 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-08-23 07:00

ISSN	2307-8960 (online)
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