Publication Name	World Journal of Hepatology
Manuscript ID	85836
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Liver disease epidemiology and burden in patients with alterations in plasma protein metabolism: German retrospective insurance claims analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Nils Picker, May Hagiwara, Severin Baumann, Ed G Marins, Thomas Wilke, Kaili Ren, Ulf Maywald, Chitra Karki and Pavel Strnad
Funding Agency and Grant Number
Corresponding Author	Pavel Strnad, MD, Professor, Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, 30 Pauwelsstraße, Aachen 52074, Germany. pstrnad@ukaachen.de
Key Words	Alpha-1 antitrypsin deficiency; Epidemiology; Germany; Liver diseases; Retrospective study
Core Tip	This was a retrospective analysis of anonymized, patient-level, insurance claims data from a German health insurance provider (AOK PLUS), which demonstrated that a diagnosis of alterations in plasma protein metabolism (APPM) (E88.0) in patients with liver disease was associated with a substantial burden and higher rate of liver disease progression compared with patients with liver disease but without APPM. To enable accurate diagnosis and inform disease management, it is important to have specific diagnostic codes that differentiate between genetic liver disease and liver manifestations from other causes.
Citation	Picker N, Hagiwara M, Baumann S, Marins EG, Wilke T, Ren K, Maywald U, Karki C, Strnad P. Liver disease epidemiology and burden in patients with alterations in plasma protein metabolism: German retrospective insurance claims analysis. World J Hepatol 2023; 15(10): 1127-1139

Received	2023-05-22 14:28
Peer-Review Started	2023-05-22 14:31
To Make the First Decision
Return for Revision	2023-07-11 15:31
Revised	2023-08-11 13:34
Second Decision	2023-09-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-09-18 08:41
Articles in Press	2023-09-18 08:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-09-14 19:16
Typeset the Manuscript	2023-10-12 00:37

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com