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Publication Name World Journal of Clinical Oncology
Manuscript ID 87022
Country/Territory China
Category Oncology
Manuscript Type Basic Study
Article Title Hub genes and their key effects on prognosis of Burkitt lymphoma
Manuscript Source Unsolicited Manuscript
All Author List Yan-Feng Xu, Guan-Yun Wang, Ming-Yu Zhang and Ji-Gang Yang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 82272034
Corresponding Author Ji-Gang Yang, MD, PhD, Chief Doctor, Professor, Researcher, Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong An Road, Xicheng District, Beijing 100050, China. yangjigang@ccmu.edu.cn
Key Words Burkitt lymphoma; Weighted gene co-expression network analysis; Microarray data; Functional enrichment analysis; Prognosis; Therapeutic target
Core Tip This study represents the pioneering investigation of gene expression in Burkitt lymphoma (BL) using weighted gene co-expression network analysis, coupled with functional enrichment analysis. In this study, we have successfully identified and validated 10 hub genes. Survival analysis has demonstrated that the overexpression of CXCL10 and IL2RA in BL may serve as robust prognostic indicators. Furthermore, an integrated mRNA signature and age nomogram potentially provide valuable prognostic insights for patients with BLs.
Citation Xu YF, Wang GY, Zhang MY, Yang JG. Hub genes and their key effects on prognosis of Burkitt lymphoma. World J Clin Oncol 2023; In press
2023-07-19 11:35
Peer-Review Started
2023-07-19 11:37
To Make the First Decision
Return for Revision
2023-08-24 08:10
2023-09-06 11:32
Second Decision
2023-09-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-09-18 08:44
Articles in Press
2023-09-18 08:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Cong Lin
Reviewer Code 05776245, and 06125275
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma