Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	87031
Country	United States

Category	Oncology
Manuscript Type	Case Report
Article Title	Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Blake Buzard, Lindsey Douglass, Beth Gustafson, Jennifer Buckley, Marc Roth, Lara Kujtan and Dhruv Bansal
Funding Agency and Grant Number
Corresponding Author	Lara Kujtan, MD, Associate Professor, Department of Medical Oncology, University of Missouri - Kansas City, No. 2310 Holmes St, Kansas, MO 64108, United States. kujtanl@umsystem.edu
Key Words	Colorectal cancer; Osimertinib; Epidermal growth factor receptor T790M; Precision oncology; Tyrosine kinase inhibitor; Case report
Core Tip	Somatic epidermal growth factor receptor (EGFR) mutations are rarely found in colorectal cancer. Treatment with anti-EGFR antibodies is commonplace, but EGFR tyrosine kinase inhibitors are not standard in colorectal cancer. Here we report a case of sustained response to osimertinib in a metastatic colorectal cancer patient with an EGFR T790M mutation detected with cell-free DNA. She progressed on three lines of treatment, and received fourth-line treatment with off-label osimertinib, with clinical response. She received treatment with osimertinib for seven months. This case shows the benefit of multi-gene sequencing assays to identify potential therapeutic options in patients with refractory disease.
Citation	Buzard B, Douglass L, Gustafson B, Buckley J, Roth M, Kujtan L, Bansal D. Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report. World J Gastrointest Oncol 2023; 15(10): 1829-1834

Received	2023-07-21 20:38
Peer-Review Started	2023-07-21 20:40
To Make the First Decision
Return for Revision	2023-08-23 03:02
Revised	2023-09-06 15:24
Second Decision	2023-09-18 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-09-18 22:24
Articles in Press	2023-09-18 22:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-10-06 13:39

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com