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Articles in Press
9/18/2023 10:24:28 PM | Browse: 26 | Download: 0
| Publication Name |
World Journal of Gastrointestinal Oncology |
| Manuscript ID |
87031 |
| Country/Territory |
United States |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Blake Buzard, Lindsey Douglass, Beth Gustafson, Jennifer Buckley, Marc Roth, Lara Kujtan and Dhruv Bansal |
| Funding Agency and Grant Number |
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| Corresponding Author |
Lara Kujtan, MD, Associate Professor, Department of Medical Oncology, University of Missouri - Kansas City, No. 2310 Holmes St, Kansas, MO 64108, United States. kujtanl@umsystem.edu |
| Key Words |
Colorectal cancer; Osimertinib; Epidermal growth factor receptor T790M; Precision oncology; Tyrosine kinase inhibitor; Case report |
| Core Tip |
Somatic epidermal growth factor receptor (EGFR) mutations are rarely found in colorectal cancer. Treatment with anti-EGFR antibodies is commonplace, but EGFR tyrosine kinase inhibitors are not standard in colorectal cancer. Here we report a case of sustained response to osimertinib in a metastatic colorectal cancer patient with an EGFR T790M mutation detected with cell-free DNA. She progressed on three lines of treatment, and received fourth-line treatment with off-label osimertinib, with clinical response. She received treatment with osimertinib for seven months. This case shows the benefit of multi-gene sequencing assays to identify potential therapeutic options in patients with refractory disease. |
| Citation |
Buzard B, Douglass L, Gustafson B, Buckley J, Roth M, Kujtan L, Bansal D. Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report. World J Gastrointest Oncol 2023; In press |
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Received |
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2023-07-21 20:38 |
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Peer-Review Started |
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2023-07-21 20:40 |
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To Make the First Decision |
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Return for Revision |
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2023-08-23 03:02 |
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Revised |
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2023-09-06 15:24 |
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Second Decision |
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2023-09-18 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-09-18 22:24 |
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Articles in Press |
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2023-09-18 22:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Assistant Editor |
Assistant Editor |
| Science Editor |
Cong Lin |
| Reviewer Code |
03072664, and 03270441 |
| Editorial Director |
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| Journal Chief Editor |
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| Company Chief Editor |
Li Ma |
| Language Editor |
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| Production Editor |
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| Responsible Production Editor |
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| Responsible Science Editor |
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| Proofing Editorial Director |
Jin-Lei Wang |
| Proofing Editor-in-Chief |
Lian-Sheng Ma |
© 2004-2023 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
