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9/18/2023 10:24:28 PM | Browse: 26 | Download: 0
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 87031
Country/Territory United States
Category Oncology
Manuscript Type Case Report
Article Title Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report
Manuscript Source Unsolicited Manuscript
All Author List Blake Buzard, Lindsey Douglass, Beth Gustafson, Jennifer Buckley, Marc Roth, Lara Kujtan and Dhruv Bansal
Funding Agency and Grant Number
Corresponding Author Lara Kujtan, MD, Associate Professor, Department of Medical Oncology, University of Missouri - Kansas City, No. 2310 Holmes St, Kansas, MO 64108, United States. kujtanl@umsystem.edu
Key Words Colorectal cancer; Osimertinib; Epidermal growth factor receptor T790M; Precision oncology; Tyrosine kinase inhibitor; Case report
Core Tip Somatic epidermal growth factor receptor (EGFR) mutations are rarely found in colorectal cancer. Treatment with anti-EGFR antibodies is commonplace, but EGFR tyrosine kinase inhibitors are not standard in colorectal cancer. Here we report a case of sustained response to osimertinib in a metastatic colorectal cancer patient with an EGFR T790M mutation detected with cell-free DNA. She progressed on three lines of treatment, and received fourth-line treatment with off-label osimertinib, with clinical response. She received treatment with osimertinib for seven months. This case shows the benefit of multi-gene sequencing assays to identify potential therapeutic options in patients with refractory disease.
Citation Buzard B, Douglass L, Gustafson B, Buckley J, Roth M, Kujtan L, Bansal D. Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report. World J Gastrointest Oncol 2023; In press
2023-07-21 20:38
Peer-Review Started
2023-07-21 20:40
To Make the First Decision
Return for Revision
2023-08-23 03:02
2023-09-06 15:24
Second Decision
2023-09-18 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-09-18 22:24
Articles in Press
2023-09-18 22:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Cong Lin
Reviewer Code 03072664, and 03270441
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma