Publication Name	World Journal of Clinical Cases
Manuscript ID	87303
Country	China

Category	Hematology
Manuscript Type	Observational Study
Article Title	Effect of T-regulatory cells and interleukin-35, interleukin-10, and transforming growth factor-beta on diffuse large B-cell lymphoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hao Wu, Hui-Cong Sun and Gui-Fang Ouyang
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang TCM Science and Technology Project 2023ZL653 Zhejiang Medical Science and Technology Plan Project-Clinical Research Application Project A 2021KY273
Corresponding Author	Gui-Fang Ouyang, MD, Chief Physician, Department of Hematology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo 315010, Zhejiang Province, China. oyguifangoy@163.com
Key Words	Diffuse large B-cell lymphoma; T-regulatory cells; Interleukin-35; Interleukin-10; Transforming growth factor-beta; Immune response
Core Tip	To study the expression and significance of T-regulatory cells (Tregs) interleukin (IL)-35, IL-10, and transforming growth factor-beta (TGF-β) in diffuse large B-cell lymphoma (DLBCL). Seventy-nine patients were enrolled and divided into three groups according to the evaluation of clinical efficacy: Incipient, effectively treated, and relapsed-refractory. Thirty healthy individuals comprised the control group. The expression of Tregs and their associated factors IL-35, IL-10, and TGF-β in the four groups were analyzed. Finally, we found that Tregs, IL-35, and IL-10 are closely associated with the occurrence and development of DLBCL, which may be helpful in the analysis of disease prognosis.
Citation	Wu H, Sun HC, Ouyang GF. Effect of T-regulatory cells and interleukin-35, interleukin-10, and transforming growth factor-beta on diffuse large B-cell lymphoma. World J Clin Cases 2023; 11(29): 7075-7081

Received	2023-08-08 10:35
Peer-Review Started	2023-08-04 09:06
To Make the First Decision
Return for Revision	2023-08-24 07:00
Revised	2023-09-08 07:42
Second Decision	2023-09-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-09-18 06:54
Articles in Press	2023-09-18 06:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-25 07:13

ISSN	2307-8960 (online)
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