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Publication Name World Journal of Clinical Cases
Manuscript ID 87521
Country India
Category Ophthalmology
Manuscript Type Retrospective Study
Article Title Axenfeld-Reiger syndrome: A search for the missing links
Manuscript Source Invited Manuscript
All Author List Arvind Kumar Morya, Prasanna Venkatesh Ramesh, Sony Sinha, Prateek Nishant, Nazia Nain, Ravi Naik Ramavath, Chetana Gone and Ripunjay Prasad
Funding Agency and Grant Number
Corresponding Author Arvind Kumar Morya, MBBS, MNAMS, MS, Additional Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Bibi Nagar, Hyderabad 508126, Telangana, India. bulbul.morya@gmail.com
Key Words Axenfeld-Reiger Syndrome; Glaucoma; Limbal stem cell deficiency; Vernal keratoconjuctivitis
Core Tip Clinical characteristic of Axenfeld-Rieger syndrome (ARS) is well defined and approximately 50% develop glaucoma later in life. Despite significant progress in unraveling the genetic basis of ARS, many questions still remain unanswered. One of the key challenges in studying this syndrome is the wide variability in clinical presentation, even among individuals with the same underlying genetic mutation. This suggests the involvement of additional genetic and environmental factors that modulate the phenotypic expression of the syndrome. Researchers are actively exploring epigenetic modifications, gene-gene interactions, and gene-environment interactions to uncover these missing links.
Citation Morya AK, Ramesh PV, Sinha S, Nishant P, Nain N, Ramavath RN, Gone C, Prasad R. Axenfeld-reiger syndrome: A search for the missing links. World J Clin Cases 2023; 11(29): 7034-7042
Received
2023-08-17 07:45
Peer-Review Started
2023-08-17 07:45
To Make the First Decision
Return for Revision
2023-09-04 02:53
Revised
2023-09-12 12:22
Second Decision
2023-09-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-09-18 08:33
Articles in Press
2023-09-18 08:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-09-25 07:12
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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