Publication Name	World Journal of Clinical Cases
Manuscript ID	87521
Country	India

Category	Ophthalmology
Manuscript Type	Retrospective Study
Article Title	Axenfeld-Reiger syndrome: A search for the missing links
Manuscript Source	Invited Manuscript
All Author List	Arvind Kumar Morya, Prasanna Venkatesh Ramesh, Sony Sinha, Prateek Nishant, Nazia Nain, Ravi Naik Ramavath, Chetana Gone and Ripunjay Prasad
Funding Agency and Grant Number
Corresponding Author	Arvind Kumar Morya, MBBS, MNAMS, MS, Additional Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Bibi Nagar, Hyderabad 508126, Telangana, India. bulbul.morya@gmail.com
Key Words	Axenfeld-Reiger Syndrome; Glaucoma; Limbal stem cell deficiency; Vernal keratoconjuctivitis
Core Tip	Clinical characteristic of Axenfeld-Rieger syndrome (ARS) is well defined and approximately 50% develop glaucoma later in life. Despite significant progress in unraveling the genetic basis of ARS, many questions still remain unanswered. One of the key challenges in studying this syndrome is the wide variability in clinical presentation, even among individuals with the same underlying genetic mutation. This suggests the involvement of additional genetic and environmental factors that modulate the phenotypic expression of the syndrome. Researchers are actively exploring epigenetic modifications, gene-gene interactions, and gene-environment interactions to uncover these missing links.
Citation	Morya AK, Ramesh PV, Sinha S, Nishant P, Nain N, Ramavath RN, Gone C, Prasad R. Axenfeld-reiger syndrome: A search for the missing links. World J Clin Cases 2023; 11(29): 7034-7042

Received	2023-08-17 07:45
Peer-Review Started	2023-08-17 07:45
To Make the First Decision
Return for Revision	2023-09-04 02:53
Revised	2023-09-12 12:22
Second Decision	2023-09-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-09-18 08:33
Articles in Press	2023-09-18 08:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-25 07:12

ISSN	2307-8960 (online)
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