Publication Name	World Journal of Diabetes
Manuscript ID	100260
Country	China

Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Mesenchymal stem cell-derived extracellular vesicles: A promising therapeutic strategy in diabetic osteoporosis
Manuscript Source	Invited Manuscript
All Author List	Ya-Jing Yang, Xi-Er Chen, Xu-Chang Zhou and Feng-Xia Liang
Funding Agency and Grant Number
Corresponding Author	Feng-Xia Liang, PhD, Chief Physician, Professor, Preventive Treatment of Acupuncture and Moxibustion of Hubei Provincial Collaborative Innovation Center, College of Acupuncture-Moxibustion and Orthopaedics of Hubei University of Chinese Medicine, No. 1 West Huangjiahu Road, Qingling Street, Hongshan District, Wuhan 430065, Hubei Province, China. fxliang5@hotmail.com
Key Words	Bone marrow mesenchymal stem cells; Adipose-derived mesenchymal stem cells; extracellular vesicles; MicroRNAs; Long non-coding RNAs; Diabetic osteoporosis
Core Tip	A sustained high-glucose microenvironment may impair bone homeostasis leading to the initiation and progression of diabetic osteoporosis (DOP) in patients with diabetes mellitus (DM). Correcting the uncoupled bone remodelling and inflammatory microenvironment is the key to treating DOP. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have received widespread attention due to their ability to promote bone regeneration and inhibit bone loss in the treatment of osteoporosis by targeting the delivery of modifiable cargoes. This suggests that MSC-EVs also have great potential for the treatment of DOP, although the condition of DOP patients is more complex due to the fact that DOP patients are usually also accompanied by multiple cardiovascular and cerebrovascular complications and long-term use of multiple medications. Rapid advances in genetic engineering and bioengineering have also enabled modifiable MSC-EVs to show significant advantages in personalised and tailored treatment cases. More studies are needed to further demonstrate and develop the clinical therapeutic potential of MSC-EVs in DOP.
Citation	<p>Yang YJ, Chen XE, Zhou XC, Liang FX. Mesenchymal stem cell-derived extracellular vesicles: A promising therapeutic strategy in diabetic osteoporosis. <i>World J Diabetes</i> 2024; 15(12): 2399-2403</p>

Received	2024-08-11 22:52
Peer-Review Started	2024-08-19 00:25
To Make the First Decision
Return for Revision	2024-09-17 20:40
Revised	2024-09-27 15:50
Second Decision	2024-10-30 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-30 13:45
Articles in Press	2024-10-30 13:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-06 04:03

ISSN	1948-9358 (online)
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