Publication Name	World Journal of Hepatology
Manuscript ID	100509
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Influence of nonalcoholic fatty liver disease on the therapeutic effect of nucleoside (acid) analogs for hepatitis B virus
Manuscript Source	Unsolicited Manuscript
All Author List	Hua-Dong Li, Ya-Nan Liu, Shuang Wu, Xu-Feng Quan, Xiao-Yan Wang, Tian-Dan Xiang, Shu-Meng Li, Ling Xu, Tong Wang, Hua Wang and Xin Zheng
Funding Agency and Grant Number	Funding Agency Grant Number Wuhan Science and Technology Bureau Knowledge Innovation Special Foundation of Hubei Province 2022020801010588 National Key R and D Projects 2022YFC2305100 National Science and Technology Major Project of China 92169121
Corresponding Author	Xin Zheng, MD, PhD, Professor, Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. xinz@hust.edu.cn
Key Words	Nonalcoholic fatty liver disease; Chronic hepatitis B; Nucleoside analogues; Antiviral therapy; Virological response
Core Tip	The effect of nonalcoholic fatty liver disease (NAFLD) on the antiviral therapy with nucleoside analogues (NAs) in patients with chronic hepatitis B (CHB) is controversial. The aim of this study was to investigate the virological response to first-line NAs antiviral treatment in patients with NAFLD and CHB, through dynamically monitoring virology indicators for 96 weeks, to determine the influence of NAFLD on the efficacy of NAs anti- hepatitis B virus treatment. To our knowledge, this is the first grading study based on HBV baseline viral load that confirms a reduction in virological response to NAs antiviral treatment caused by NAFLD.
Citation	<p>Li HD, Liu YN, Wu S, Quan XF, Wang XY, Xiang TD, Li SM, Xu L, Wang T, Wang H, Zheng X. Influence of nonalcoholic fatty liver disease on the therapeutic effect of nucleoside (acid) analogs for hepatitis B virus. <i>World J Hepatol</i> 2024; 16(12): 1395-1406</p>

Received	2024-08-18 14:18
Peer-Review Started	2024-08-18 14:18
To Make the First Decision
Return for Revision	2024-09-18 03:14
Revised	2024-10-02 01:04
Second Decision	2024-10-29 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 11:10
Articles in Press	2024-10-29 11:10
Publication Fee Transferred	2024-10-31 16:01
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-22 01:41

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com