Publication Name	World Journal of Gastroenterology
Manuscript ID	100752
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt: Mechanistic and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Qi-Rong Jiang and Da-Wu Zeng
Funding Agency and Grant Number	Funding Agency Grant Number Clinical Research Center for Hepatopathy and Intestinal Diseases of Fujian Province 2023GBYJ-YL-1
Corresponding Author	Da-Wu Zeng, MD, Department of Infectious Diseases, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fujian 515421, China. zengdw1980@fjmu.edu.cn
Key Words	Hepatitis B virus; Cirrhosis; Portal hypertension; Hepatic encephalopathy; Transjugular intrahepatic portosystemic shunt; Gut microbiota
Core Tip	Shifts in gut microbiome composition are closely related to hepatic encephalopathy, yet there is limited research on changes before and after transjugular intrahepatic portosystemic shunt (TIPS) in hepatitis B virus-related portal hypertension patients. The findings by Zhao et al highlight the potential involvement of the bacterial genus Morganella in post-TIPS hepatic encephalopathy. Meanwhile, they also emphasize the importance of the elevation of probiotics in post-TIPS patients without hepatic encephalopathy. Future studies with a larger sample size and a longer evaluation period are needed to address dynamic gut microbiota changes post-TIPS, their correlation with blood ammonia levels, and clinical outcomes.
Citation	Jiang QR, Zeng DW. Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt: Mechanistic and clinical implications. World J Gastroenterol 2024; In press

Received	2024-08-26 02:35
Peer-Review Started	2024-09-05 01:17
To Make the First Decision
Return for Revision	2024-11-01 03:48
Revised	2024-11-07 13:04
Second Decision	2024-11-28 02:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-28 06:14
Articles in Press	2024-11-28 06:14
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ISSN	1007-9327 (print) and 2219-2840 (online)
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