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Articles in Press
10/30/2024 2:03:14 PM | Browse: 62 | Download: 0
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Report |
| Article Title |
Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Chuan Yang, Zhi-Tao Chen, Da-Long Wan, Hui Tang and Mu-Lin Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| School-Level Key Projects at Bengbu Medical College |
2021byzd109 |
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| Corresponding Author |
Mu-Lin Liu, PhD, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. liumulin66@aliyun.com |
| Key Words |
Gallbladder neuroendocrine carcinoma; Targeted-gene sequencing; Bioinformatics analysis; case report; Immunocytochemistry; Case report |
| Core Tip |
Gallbladder neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy with unclear genetic alterations and mechanisms. Our case study of a 73-year-old female with gallbladder NEC revealed 12 mutated genes (APC, ARID2, IFNA6, KEAP1, RB1, SMAD4, TP53, BTK, GATA1, GNAS, JAK2, PRDM3) and a high tumor mutation burden. Bioinformatic analysis identified significant protein-protein interactions and tumor-related functions/pathways, highlighting key regulatory factors. Gallbladder NEC exhibits distinct molecular profiles compared to other gallbladder carcinomas, emphasizing the need for tailored therapeutic strategies and further research to unravel its underlying biology. |
| Citation |
Yang YC, Chen ZT, Wan DL, Tang H, Liu ML. Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report. World J Gastrointest Oncol 2025; 17(1): 100757 |
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Received |
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2024-08-26 02:39 |
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Peer-Review Started |
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2024-09-05 01:18 |
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First Decision by Editorial Office Director |
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2024-09-15 20:23 |
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Return for Revision |
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2024-09-17 07:47 |
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Revised |
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2024-09-26 11:19 |
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Publication Fee Transferred |
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2024-11-04 05:04 |
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Second Decision by Editor |
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2024-10-30 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-30 14:03 |
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Articles in Press |
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2024-10-30 14:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-11-20 08:36 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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