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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 100757
Country China
Category Medicine, Research & Experimental
Manuscript Type Case Report
Article Title Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report
Manuscript Source Unsolicited Manuscript
All Author List Yun-Chuan Yang, Zhi-Tao Chen, Da-Long Wan, Hui Tang and Mu-Lin Liu
Funding Agency and Grant Number
Funding Agency Grant Number
School-Level Key Projects at Bengbu Medical College 2021byzd109
Corresponding Author Mu-Lin Liu, PhD, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. liumulin66@aliyun.com
Key Words Gallbladder neuroendocrine carcinoma; Targeted-gene sequencing; Bioinformatics analysis; case report; Immunocytochemistry; Case report
Core Tip Gallbladder neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy with unclear genetic alterations and mechanisms. Our case study of a 73-year-old female with gallbladder NEC revealed 12 mutated genes (APC, ARID2, IFNA6, KEAP1, RB1, SMAD4, TP53, BTK, GATA1, GNAS, JAK2, PRDM3) and a high tumor mutation burden. Bioinformatic analysis identified significant protein-protein interactions and tumor-related functions/pathways, highlighting key regulatory factors. Gallbladder NEC exhibits distinct molecular profiles compared to other gallbladder carcinomas, emphasizing the need for tailored therapeutic strategies and further research to unravel its underlying biology.
Citation Yang YC, Chen ZT, Wan DL, Tang H, Liu ML. Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report. World J Gastrointest Oncol 2024; In press
Received
2024-08-26 02:39
Peer-Review Started
2024-09-05 01:18
To Make the First Decision
Return for Revision
2024-09-17 07:47
Revised
2024-09-26 11:19
Second Decision
2024-10-30 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-10-30 14:03
Articles in Press
2024-10-30 14:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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