Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	100951
Country	China

Category	Surgery
Manuscript Type	Case Report
Article Title	Lung metastasis following temporary discontinuation of lenvatinib and tislelizumab in hepatocellular carcinoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Dong Wang, Run-Dong Liu, Ming-Jie Liu and Jia Song
Funding Agency and Grant Number
Corresponding Author	Jia Song, PhD, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430022, Hubei Province, China. tjhsongjia@hust.edu.cn
Key Words	Hepatocellular carcinoma; Hepatic arterial infusion chemotherapy; Lenvatinib; Tislelizumab; Conversion therapy; Case report
Core Tip	In recent years, targeted therapies, immunotherapies with immune checkpoint inhibitors, and localized interventions have effectively managed advanced or non-resectable hepatocellular carcinoma (HCC). Despite these advances, few studies have addressed the crucial need for management strategies during the perioperative period for patients with HCC. To our knowledge, this is the first report to illuminate the potential risk of disease progression and lung metastasis after the temporary cessation of targeted therapy with lenvatinib and immunotherapy with tislelizumab. This finding reveals the importance of refining treatment protocols to reduce the risks of recurrence and metastasis.
Citation	Wang CD, Liu RD, Liu MJ, Song J. Lung metastasis following temporary discontinuation of lenvatinib and tislelizumab in hepatocellular carcinoma: A case report. World J Gastrointest Surg 2025; In press

Received	2024-08-31 05:40
Peer-Review Started	2024-09-05 05:52
To Make the First Decision
Return for Revision	2024-11-23 05:41
Revised	2024-12-04 05:41
Second Decision	2025-01-10 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-10 07:12
Articles in Press	2025-01-10 07:12
Publication Fee Transferred	2024-12-17 15:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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