Publication Name	World Journal of Experimental Medicine
Manuscript ID	101277
Country	India

Category	Biotechnology & Applied Microbiology
Manuscript Type	Review
Article Title	Understanding the intricate interactions between microbiota and host
Manuscript Source	Invited Manuscript
All Author List	Aiysha Siddiq Khan, Mohan Kamthan and Asghar Ali
Funding Agency and Grant Number	Funding Agency Grant Number Indian Council of Medical Research Government of India 2021-10264/GTGE-BMS Department of Health Research, Government of India R.12014/61/2022-HR
Corresponding Author	Asghar Ali, PhD, Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, Delhi, India. asgharali@jamiahamdard.ac.in
Key Words	Gut microbiota; Microbiota-host relationship; Immune system; Faecal microbiome transplantation; Probiotics; Gut dysbiosis; Chronic disorders; Gastrointestinal tract; Metabolic disorders; Gut-organ axis
Core Tip	This review article explores the crucial role of gut microbiota and their metabolites in immune regulation, gene expression, and disease progression. It introduces the gut-organ axis hypothesis, linking systemic genetic factors with inflammatory bowel disease progression and treatment response. The study emphasizes microbiota-targeted therapies, such as probiotics, fecal microbiota transplantation, and dietary interventions, as promising strategies in precision medicine. Future research should focus on personalized microbiome-based treatments, leveraging machine learning and advanced analytics to optimize therapies. These insights pave the way for microbiome-driven interventions, revolutionizing treatments for inflammatory bowel disease, autoimmune diseases, and cancer.
Citation	Khan AS, Kamthan M, Ali A. Understanding the intricate interactions between microbiota and host. World J Exp Med 2025; In press

Received	2024-09-11 04:01
Peer-Review Started	2024-09-14 03:02
To Make the First Decision
Return for Revision	2025-02-13 03:05
Revised	2025-02-26 17:03
Second Decision	2025-04-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-14 07:44
Articles in Press	2025-04-14 07:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-08 08:31

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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