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Publication Name World Journal of Experimental Medicine
Manuscript ID 101277
Country India
Category Biotechnology & Applied Microbiology
Manuscript Type Review
Article Title Understanding the intricate interactions between microbiota and host
Manuscript Source Invited Manuscript
All Author List Aiysha Siddiq Khan, Mohan Kamthan and Asghar Ali
Funding Agency and Grant Number
Funding Agency Grant Number
Indian Council of Medical Research Government of India 2021-10264/GTGE-BMS
Department of Health Research, Government of India R.12014/61/2022-HR
Corresponding Author Asghar Ali, PhD, Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, Delhi, India. asgharali@jamiahamdard.ac.in
Key Words Gut microbiota; Microbiota-host relationship; Immune system; Faecal microbiome transplantation; Probiotics; Gut dysbiosis; Chronic disorders; Gastrointestinal tract; Metabolic disorders; Gut-organ axis
Core Tip This review article explores the crucial role of gut microbiota and their metabolites in immune regulation, gene expression, and disease progression. It introduces the gut-organ axis hypothesis, linking systemic genetic factors with inflammatory bowel disease progression and treatment response. The study emphasizes microbiota-targeted therapies, such as probiotics, fecal microbiota transplantation, and dietary interventions, as promising strategies in precision medicine. Future research should focus on personalized microbiome-based treatments, leveraging machine learning and advanced analytics to optimize therapies. These insights pave the way for microbiome-driven interventions, revolutionizing treatments for inflammatory bowel disease, autoimmune diseases, and cancer.
Citation Khan AS, Kamthan M, Ali A. Understanding the intricate interactions between microbiota and host. World J Exp Med 2025; In press
Received
2024-09-11 04:01
Peer-Review Started
2024-09-14 03:02
To Make the First Decision
Return for Revision
2025-02-13 03:05
Revised
2025-02-26 17:03
Second Decision
2025-04-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-04-14 07:44
Articles in Press
2025-04-14 07:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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