Publication Name	World Journal of Gastroenterology
Manuscript ID	101357
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage
Manuscript Source	Invited Manuscript
All Author List	Raffaele Pellegrino and Antonietta Gerarda Gravina
Funding Agency and Grant Number
Corresponding Author	Raffaele Pellegrino, MD, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L De Crecchio, Naples 80138, Italy. raffaele.pellegrino@unicampania.it
Key Words	Neuroendocrine axis; Gut microbiota; Inflammatory response; Irritable bowel syndrome; Functional gastrointestinal disorders; Biopsychosocial model; Mucosal inflammation; Cytokines; Serotonergic system; Melanocortin system
Core Tip	This letter highlights the complex interplay between the neuroendocrine axis, gut microbiota, and inflammatory response in irritable bowel syndrome (IBS). By adopting a multiparametric approach, the findings proposed by the commented article suggest that IBS involves both gastrointestinal and neuroendocrine factors, supporting the biopsychosocial model for understanding and managing functional gastrointestinal disorders.
Citation	<p>Pellegrino R, Gravina AG. Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage. <i>World J Gastroenterol</i> 2025; 31(8): 101357</p>

Received	2024-09-11 14:40
Peer-Review Started	2024-09-11 14:40
To Make the First Decision
Return for Revision	2024-12-29 01:22
Revised	2024-12-29 19:29
Second Decision	2025-01-06 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-06 05:19
Articles in Press	2025-01-06 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-01-11 03:59
Typeset the Manuscript	2025-01-15 08:37

ISSN	1007-9327 (print) and 2219-2840 (online)
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