Publication Name	World Journal of Gastroenterology
Manuscript ID	101594
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Establishment of a chronic biliary disease mouse model with cholecystoduodenal anastomosis for intestinal microbiome preservation
Manuscript Source	Unsolicited Manuscript
All Author List	Yunseon Jang, Jung Yeon Kim, Song Yeon Han, Arum Park, So Jeong Baek, Gyurim Lee, Jihee Kang, Hyewon Ryu and Seok-Hwan Kim
Funding Agency and Grant Number	Funding Agency Grant Number Korea Health Technology R&D Project through the Korea Health Industry Development Institute, Funded by the Ministry of Health & Welfare, Republic of Korea HI22C12HR20C0025 and HI22C1212 the National Research Foundation of Korea Grant Funded by the Korea Government RS-2023-00238188
Corresponding Author	Seok-Hwan Kim, MD, PhD, Assistant Professor, Department of Surgery, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, South Korea. kjxh7@cnuh.co.kr
Key Words	Experimental animal model; Cholecystoduodenal fistula; Anastomosis; Biliary Disease; Microbiome
Core Tip	This study introduces a novel cholecystoduodenal anastomosis mouse model to replicate the ascending infection and inflammation observed in human biliary diseases without the use of antibiotics. The model demonstrates localized biliary inflammation and microbial dysbiosis, particularly involving Escherichia coli and Enterococcus, closely mimicking human conditions. This model offers a valuable platform for investigating microbiome-based therapies aimed at preventing and treating chronic biliary diseases.
Citation	<p>Jang Y, Kim JY, Han SY, Park A, Baek SJ, Lee G, Kang J, Ryu H, Kim SH. Establishment of a chronic biliary disease mouse model with cholecystoduodenal anastomosis for intestinal microbiome preservation. <i>World J Gastroenterol</i> 2024; 30(46): 4937-4946</p>

Received	2024-09-20 04:38
Peer-Review Started	2024-09-20 04:38
To Make the First Decision
Return for Revision	2024-10-15 03:24
Revised	2024-10-22 00:50
Second Decision	2024-10-30 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-30 14:16
Articles in Press	2024-10-30 14:16
Publication Fee Transferred	2024-11-04 01:06
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-12 06:17

ISSN	1007-9327 (print) and 2219-2840 (online)
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