Publication Name	World Journal of Stem Cells
Manuscript ID	101929
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Xiang Zeng, Jin-Tao Ye, Si-Hua Huang and Ruo-Xi Liu
Funding Agency and Grant Number
Corresponding Author	Si-Hua Huang, Associate Chief Physician, MD, Department of Orthopaedic Surgery, Second Affiliated Hospital of Medical School of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. mbyp180@163.com
Key Words	Spinal cord injury; Neural stem cell; X inactive-specific transcript; Mitochondrial function; Neuronal differentiation
Core Tip	This study highlights the critical role of long non-coding RNA X inactive-specific transcript (XIST) in enhancing neural stem cell function for spinal cord injury (SCI) treatment. XIST significantly improves motor recovery and reduces inflammation in mouse models of SCI by promoting mitochondrial function and neuronal differentiation. These findings suggest that XIST regulates carnitine palmitoyl transferase 1A expression via the insulin-like growth factor 2 mRNA binding protein 2 pathway, providing a promising therapeutic target for the development of effective interventions against irreversible neurological deficits in SCI. Further exploration of the long-term effects of XIST may advance its clinical applications.
Citation	Zeng SX, Ye JT, Huang SH, Liu RX. X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury. World J Stem Cells 2025; In press

Received	2025-02-12 08:10
Peer-Review Started	2025-02-12 08:10
To Make the First Decision
Return for Revision	2025-02-26 05:00
Revised	2025-03-07 16:43
Second Decision	2025-06-09 09:47
Accepted by Journal Editor-in-Chief	2025-06-14 06:43
Accepted by Executive Editor-in-Chief	2025-06-25 08:06
Articles in Press	2025-06-25 08:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-29 08:02
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com