Publication Name	World Journal of Diabetes
Manuscript ID	101966
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Wang, Yu-Xian Xu, Feng Xu, Chun-Hua Wang, Li-Hua Zhao, Li-Hua Wang, Wei-Guan Chen, Xue-Qin Wang, Cheng-Wei Duan and Jian-Bin Su
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32101027 Social Development Projects of Nantong MS12019019, HS2022004, and MS2023083 Medical Research Project of the Jiangsu Health Commission Z2022058
Corresponding Author	Jian-Bin Su, Assistant Professor, MD, Department of Endocrinology, The Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. sujbzjx@163.com
Key Words	Blood urea nitrogen; Metabolic disturbance; Peripheral nerve function; Electromyography; Type 2 diabetes
Core Tip	Blood urea nitrogen (BUN) is a well-established biomarker utilized in clinical diagnostic evaluations. When renal function is relatively normal, an increase in BUN may indicate a negative nitrogen balance, underlying metabolic disorders, and potential adverse outcomes. In the present study, our findings indicate that increased BUN levels are independently associated with compromised peripheral nerve function in patients with type 2 diabetes (T2D) and may serve as a potential risk factor for peripheral nerve dysfunction in these patients. Future interventions to lower BUN levels by improving nutritional status and balancing protein metabolism may alleviate peripheral nerve dysfunction in patients with T2D.
Citation	Wang R, Xu YX, Xu F, Wang CH, Zhao LH, Wang LH, Chen WG, Wang XQ, Duan CW, Su JB. Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes. World J Diabetes 2025; In press

Received	2024-10-07 02:36
Peer-Review Started	2024-10-09 01:30
To Make the First Decision
Return for Revision	2024-12-05 08:59
Revised	2024-12-14 10:15
Second Decision	2025-01-02 13:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-09 07:41
Articles in Press	2025-01-09 07:41
Publication Fee Transferred	2024-12-17 11:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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